{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:39:50Z","timestamp":1775885990118,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,10]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n To compare clinical outcomes among patients with heart failure and reduced ejection fraction (HFrEF) according to body mass index (BMI) after initiating treatment with an angiotensin\u2010receptor neprilysin inhibitor (ARNI).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We gathered data from 2016 to 2020 at the University Medical Center Mannheim; 208 consecutive patients were divided into two groups according to BMI (<\u200930\u2009kg\/m\n 2<\/jats:sup>\n ;\n n<\/jats:italic>\n \u2009=\u2009116, \u2265\u200930\u2009kg\/m\n 2<\/jats:sup>\n ;\n n<\/jats:italic>\n \u2009=\u200992). Clinical outcomes, including mortality rate, all\u2010cause hospitalizations and congestion, were systematically analysed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At the 12\u2010month follow\u2010up, the mortality rate was similar in both groups (7.9% in BMI <\u200930\u2009kg\/m\n 2<\/jats:sup>\n vs. 5.6% in BMI \u2265\u200930\u2009kg\/m\n 2<\/jats:sup>\n ;\n P<\/jats:italic>\n \u2009=\u2009.76). All\u2010cause hospitalization before ARNI treatment was comparable in both groups (63.8% in BMI <\u200930\u2009kg\/m\n 2<\/jats:sup>\n vs. 57.6% in BMI \u2265\u200930\u2009kg\/m\n 2<\/jats:sup>\n ;\n P<\/jats:italic>\n \u2009=\u2009.69). After ARNI treatment, the hospitalization rate was also comparable in both groups at the 12\u2010month follow\u2010up (52.2% in BMI <\u200930\u2009kg\/m\n 2<\/jats:sup>\n vs. 53.7% in BMI \u2265\u200930\u2009kg\/m\n 2<\/jats:sup>\n ;\n P<\/jats:italic>\n \u2009=\u2009.73). Obese patients experienced more congestion compared with non\u2010obese patients at follow\u2010up, without statistical significance (6.8% in BMI <\u200930\u2009kg\/m\n 2<\/jats:sup>\n vs. 15.5% in BMI \u2265\u200930\u2009kg\/m\n 2<\/jats:sup>\n ;\n P<\/jats:italic>\n \u2009=\u2009.11). Median left ventricular ejection fraction (LVEF) improved in both groups, but significantly more in non\u2010obese compared with obese patients at the 12\u2010month follow\u2010up (from 26% [3%\u201045%] [min.\u2010max.] vs. 29% [10%\u201045%] [min.\u2010max.] [\n P<\/jats:italic>\n \u2009=\u2009.56] to 35.5% [15%\u201059%] [min.\u2010max.] vs. 30% [13%\u201050%] [min.\u2010max.] [\n P<\/jats:italic>\n \u2009=\u2009.03], respectively). The incidence of atrial fibrillation (AF), non\u2010sustained (ns) and sustained ventricular tachycardia (VT) and ventricular fibrillation (VF) was less in non\u2010obese than in obese patients after initiation of sacubitril\/valsartan at the 12\u2010month follow\u2010up (AF: 43.5% vs. 53.7%;\n P<\/jats:italic>\n \u2009=\u2009.20; nsVT: 9.8% vs. 28.4%;\n P<\/jats:italic>\n \u2009=\u2009.01; VT: 14.1% vs. 17.9%;\n P<\/jats:italic>\n \u2009=\u2009.52; VF: 7.6% vs. 13.4%;\n P<\/jats:italic>\n \u2009=\u2009.23).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The incidence of congestion in obese patients was higher compared with non\u2010obese patients. LVEF improved significantly more in non\u2010obese compared with obese HFrEF patients. Furthermore, AF and the ventricular tachyarrhythmia rate were revealed more in obesity compared with those without obesity at the 12\u2010month follow\u2010up.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.15198","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T05:53:48Z","timestamp":1688709228000},"page":"2999-3011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Incidence of atrial and ventricular arrhythmias in obese patients with heart failure with reduced ejection fraction treated with sacubitril\/valsartan"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4766-5523","authenticated-orcid":false,"given":"Mohammad","family":"Abumayyaleh","sequence":"first","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Heidelberg Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) Partner Site Heidelberg\/Mannheim Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Demmer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Krack","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Pilsinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"El\u2010Battrawy","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Bergmannsheil University Hospitals Ruhr University of Bochum Bochum Germany"},{"name":"Department of Molecular and Experimental Cardiology Institut f\u00fcr Forschung und Lehre (IFL), Ruhr University of Bocham Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assem","family":"Aweimer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Bergmannsheil University Hospitals Ruhr University of Bochum Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim Heidelberg University Heidelberg Germany"},{"name":"European Center for AngioScience (ECAS) and German Center for Cardiovascular Research (DZHK) Partner Site Heidelberg\/Mannheim Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"M\u00fcgge","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, Bergmannsheil University Hospitals Ruhr University of Bochum Bochum Germany"},{"name":"Department of Molecular and Experimental Cardiology Institut f\u00fcr Forschung und Lehre (IFL), Ruhr University of Bocham Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Center Mannheim, Medical Faculty Mannheim 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