{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:55:19Z","timestamp":1792108519495,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K11569"],"award-info":[{"award-number":["21K11569"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03529"],"award-info":[{"award-number":["22H03529"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine the association between the magnitude of weight loss and incidence of remission according to baseline characteristics in patients with diabetes in clinical settings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 39\u2009676 Japanese patients with type 2 diabetes aged \u226518\u2009years with glycated haemoglobin (HbA1c) \u22656.5% and\/or glucose\u2010lowering drug prescription were identified from databases of specialists' clinics from 1989 and followed until September 2022. Remission was diagnosed as maintaining HbA1c &lt;6.5% at least 3\u2009months after cessation of a glucose\u2010lowering drug. Factors associated with remission were evaluated by logistic regression analysis according to weight change in 1\u2009year (i.e. \u226510%, 7.0\u20109.9%, 3.0\u20106.9% reduction, &lt;3% change and \u22653.0% increase).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, 3454 remissions occurred. The rates of remission were higher in the group with the greatest reduction of body mass index (BMI) in any category examined (i.e. baseline BMI, HbA1c, duration of diabetes and treatment). The incidences of remission per 1000 person\u2010years were about 25 and 50, respectively, for those with BMI \u226522.5 and reductions in BMI of 7.0\u20109.9% and \u226510% in 1\u2009year. Remissions per 1000 person\u2010years were 99.2 and 91.8, respectively, for those with baseline HbA1c of 6.5\u20106.9 and a 10% BMI reduction and those not taking glucose\u2010lowering drugs accompanied by a 10% BMI reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Modest weight losses of 3.0\u20107.9% were significantly associated with remission, but a minimum of 10% weight loss would be required in addition to an early diagnosis to achieve a 10% remission rate in clinical settings. Our results implied that remission may be expected with a relatively lower BMI in an Asian population compared with that was reported in Western populations if accompanied by weight loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15206","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T05:52:38Z","timestamp":1688709158000},"page":"3125-3135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relationship between the magnitude of body mass index reductions and remission in patients with type 2 diabetes in real world settings: Analysis of nationwide patient registry in Japan (\n                    <scp>JDDM<\/scp>\n                    74)"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-4169","authenticated-orcid":false,"given":"Kazuya","family":"Fujihara","sequence":"first","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laymon","family":"Khin","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshiro","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurie","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahori","family":"Tsuruoka","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Yagyuda","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Kawai clinic  Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Maegawa","sequence":"additional","affiliation":[{"name":"Yasu City Hospital  Shiga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Graduate School of Medicine Kyoto University  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9521-7274","authenticated-orcid":false,"given":"Satoru","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1263-2817","authenticated-orcid":false,"given":"Hirohito","family":"Sone","sequence":"additional","affiliation":[{"name":"Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"JDDM Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci21-0034"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-2136"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-0874"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2019.00082"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003828"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15100"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14943"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14882"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14992"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15117"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S008"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-2415"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14122"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pdi.2355"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200225"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32649-0"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/837989"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.334"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.67929"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33102-1"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012512"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105033441801"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2004.06.010"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2272"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.275"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60762-X"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70006-8"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2049"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12387"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0371"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.07.003"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13196"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.2248"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.018"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1019390"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12098"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12151-4"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2003.11.024"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12971"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(90)90299-R"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1235"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2012.07.015"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-017-2874-4"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2459"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12285"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529546"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:39:10Z","timestamp":1761871150000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,7]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/dom.15206"],"URL":"https:\/\/doi.org\/10.1111\/dom.15206","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15206\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15206\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15206\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15206\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15206\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15206\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15206\/v2\/response1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,7]]},"assertion":[{"value":"2023-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}