{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:44:31Z","timestamp":1790066671249,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["848011"],"award-info":[{"award-number":["848011"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14OC0013659"],"award-info":[{"award-number":["NNF14OC0013659"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the effect of four different drug classes on soluble urokinase plasminogen activator receptor (suPAR), a biomarker active in multiple inflammatory processes and a risk factor for complications, in people with type 1 and type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted post hoc analyses of a randomized, open\u2010label, crossover trial including 26 adults with type 1 and 40 with type 2 diabetes with urinary albumin\u2010creatinine ratio \u226530 and \u2264500\u2009mg\/g assigned to 4\u2010week treatments with telmisartan 80\u2009mg, empagliflozin 10\u2009mg, linagliptin 5\u2009mg and baricitinib 2\u2009mg, separated by 4\u2010week washouts. Plasma suPAR was measured before and after each treatment. SuPAR change after each treatment was calculated and, for each individual, the best suPAR\u2010reducing drug was identified. Subsequently, the effect of the best individual drug was compared against the mean of the other three drugs. Repeated\u2010measures linear mixed\u2010effects models were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The baseline median (interquartile range) plasma suPAR was 3.5 (2.9, 4.3) ng\/mL. No overall effect on suPAR levels was observed for any one drug. The individual best\u2010performing drug varied, with baricitinib being selected for 20 participants (30%), followed by empagliflozin for 19 (29%), linagliptin for 16 (24%) and telmisartan for 11 (17%). The individual best\u2010performing drug reduced suPAR by 13.3% (95% confidence interval [CI] 3.7, 22.8;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007). The difference in suPAR response between the individual best\u2010performing drug and the other three was \u221219.7% (95% CI \u221223.1, \u221216.3;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrated no overall effect of 4\u2010week treatment with telmisartan, empagliflozin, linagliptin or baricitinib on suPAR. However, individualization of treatment might significantly reduce suPAR levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15209","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T05:55:09Z","timestamp":1688709309000},"page":"3152-3160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Overall and inter\u2010individual effect of four different drug classes on soluble urokinase plasminogen activator receptor in type 1 and type 2 diabetes"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4270-6701","authenticated-orcid":false,"given":"Viktor","family":"Rotbain Curovic","sequence":"first","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten B.","family":"Houlind","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital\u2014Amager and Hvidovre  Hvidovre Denmark"},{"name":"University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein Y. A. M.","family":"Kroonen","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen  Groningen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Jongs","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen  Groningen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie H.","family":"Zobel","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-0352","authenticated-orcid":false,"given":"Tine W.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Tavenier","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital\u2014Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Eugen\u2010Olsen","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital\u2014Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gozewijn D.","family":"Laverman","sequence":"additional","affiliation":[{"name":"ZiekenhuisGroep Twente  Almelo Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-0019","authenticated-orcid":false,"given":"Adriaan","family":"Kooy","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen  Groningen Netherlands"},{"name":"Bethesda Diabetes Research Center  Hoogeveen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Persson","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-4294","authenticated-orcid":false,"given":"Peter","family":"Rossing","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"},{"name":"University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-3730","authenticated-orcid":false,"given":"Hiddo J. 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