{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:24:52Z","timestamp":1766269492500,"version":"build-2065373602"},"reference-count":70,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515110023"],"award-info":[{"award-number":["2019A1515110023"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong","doi-asserted-by":"publisher","award":["2018GSF118176"],"award-info":[{"award-number":["2018GSF118176"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2016HQ26"],"award-info":[{"award-number":["ZR2016HQ26"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000788"],"award-info":[{"award-number":["82000788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the potential mechanism of once\u2010weekly glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RA) in the treatment of type 2 diabetes mellitus (T2DM) complicated with coronary artery disease (CAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched both Chinese and English databases for randomized controlled trials related to once\u2010weekly GLP\u20101 RA for T2DM complicated with CAD to verify the safety and efficacy of GLP\u20101 RA. The underlying mechanism was analysed by network pharmacology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 13 studies with 35\u2009563 participants were included in the analysis. The pooled analysis found that dulaglutide, exenatide and semaglutide outperformed placebo in cardiovascular outcomes in patients with T2DM, with a significant reduction in the incidence of non\u2010fatal stroke (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00). Levels of cardiovascular risk factors were significantly reduced in the once\u2010weekly GLP\u20101 RA group compared with the conventional treatment group (glycated haemoglobin:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00; fasting blood glucose:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00; weight:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00; systolic blood pressure:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00; total cholesterol:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00; low\u2010density lipoprotein cholesterol:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.00). Network pharmacology results were enriched to the renin\u2010angiotensin system, and matrix metalloproteinase 2 and renin (REN) may be the key targets. In addition, four key targets of dulaglutide, five key targets of exenatide and two key targets of semaglutide were enriched.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggests that once\u2010weekly GLP\u20101 RA may have a potential protective effect on cardiovascular events in patients with T2DM combined with CAD, possibly through the renin\u2010angiotensin system. However, further research is needed to confirm these findings and determine cause and effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15219","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T04:07:00Z","timestamp":1690949220000},"page":"3223-3234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of once\u2010weekly glucagon\u2010like peptide\u20101 receptor agonists on type 2 diabetes mellitus complicated with coronary artery disease: Potential role of the renin\u2010angiotensin system"],"prefix":"10.1111","volume":"25","author":[{"given":"Mengfan","family":"Kan","sequence":"first","affiliation":[{"name":"Teaching and Research Section of Internal Medicine, College of Medicine Shandong University of Traditional Chinese Medicine; Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital; The Third Affiliated Hospital of Shandong First Medical University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Fu","sequence":"additional","affiliation":[{"name":"Medical Integration and Practice Center Shandong University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunsheng","family":"Xu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaodi","family":"Yue","sequence":"additional","affiliation":[{"name":"College of Rehabilitation Medicine Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyu","family":"Du","sequence":"additional","affiliation":[{"name":"College of Rehabilitation Medicine Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Rehabilitation Medicine Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Third Affiliated Hospital of Shandong First Medical University; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital; Shandong Key Laboratory of Rheumatic Disease and Translational Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohong","family":"Yu","sequence":"additional","affiliation":[{"name":"Teaching and Research Section of Internal Medicine, College of Medicine Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Department of Rehabilitation Medicine The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-5074","authenticated-orcid":false,"given":"Zhongwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Third Affiliated Hospital of Shandong First Medical University; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital; Shandong Key Laboratory of Rheumatic Disease and Translational Medicine  Jinan 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