{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:16:16Z","timestamp":1792167376927,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the associations of components of the lipid panel (and its derivatives) with intra\u2010pancreatic fat deposition (IPFD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All participants underwent abdominal magnetic resonance imaging on the same 3.0\u2010Tesla scanner and IPFD was quantified. Blood samples were collected in the fasted state for analysis of lipid panel components. A series of linear regression analyses was conducted, adjusting for age, sex, ethnicity, body mass index, fasting plasma glucose, homeostatic model assessment of insulin resistance, and liver fat deposition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 348 participants were included. Remnant cholesterol (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.010) and triglyceride levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.008) were positively, and high\u2010density lipoprotein cholesterol level (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) was negatively, associated with total IPFD in the most adjusted model. Low\u2010density lipoprotein cholesterol and total cholesterol were not significantly associated with total IPFD. Of the lipid panel components investigated, remnant cholesterol explained the greatest proportion (9.9%) of the variance in total IPFD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Components of the lipid panel have different associations with IPFD. This may open up new opportunities for improving outcomes in people at high risk for cardiovascular diseases (who have normal low\u2010density lipoprotein cholesterol) by reducing IPFD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15233","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T04:07:39Z","timestamp":1690949259000},"page":"3337-3346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Remnant cholesterol, but not low\u2010density lipoprotein cholesterol, is associated with intra\u2010pancreatic fat deposition"],"prefix":"10.1111","volume":"25","author":[{"given":"Loren","family":"Skudder\u2010Hill","sequence":"first","affiliation":[{"name":"School of Medicine University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana 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