{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:14:48Z","timestamp":1793146488521,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study assessed the impact of dapagliflozin on food intake, eating behaviour, energy expenditure, magnetic resonance imaging (MRI)\u2010determined brain response to food cues and body composition in patients with type 2 diabetes mellitus (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Patients were given dapagliflozin 10\u2009mg once daily in a randomized, double\u2010blind, placebo\u2010controlled trial with short\u2010term (1\u2009week) and long\u2010term (12\u2009weeks) cross\u2010over periods. The primary outcome was the difference in test meal food intake between long\u2010term dapagliflozin and placebo treatment. Secondary outcomes included short\u2010term differences in test meal food intake, short\u2010 and long\u2010term differences in appetite and eating rate, energy expenditure and functional MRI brain activity in relation to food images. We determined differences in glycated haemoglobin, weight, liver fat (by\n                      <jats:sup>1<\/jats:sup>\n                      H magnetic resonance spectroscopy) and subcutaneous\/visceral adipose tissue volumes (by MRI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 52 patients (43% were women) were randomized; with the analysis of 49 patients: median age 58\u2009years, weight 99.1\u2009kg, body mass index 35\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , glycated haemoglobin 49\u2009mmol\/mol. Dapagliflozin reduced glycated haemoglobin by 9.7\u2009mmol\/mol [95% confidence interval (CI) 3.91\u201016.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.004], and body weight (\u22122.84 vs. \u22120.87\u2009kg) versus placebo. There was no short\u2010 or long\u2010term difference in test meal food intake between dapagliflozin and placebo [mean difference 5.7\u2009g (95% CI \u2212127.9 to 139.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.933); 15.8\u2009g (95% CI \u2212147.7 to 116.1,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.813), respectively] nor in the rate of eating, energy expenditure, appetite, or brain responses to food cues. Liver fat (median reduction \u22124.7 vs. 1.95%), but not subcutaneous\/visceral adipose tissue, decreased significantly with 12\u2009weeks of dapagliflozin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The reduction in body weight and liver fat with dapagliflozin was not associated with compensatory adaptations in food intake or energy expenditure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15257","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T03:30:42Z","timestamp":1693884642000},"page":"3621-3631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["No evidence of compensatory changes in energy balance, despite reductions in body weight and liver fat, during dapagliflozin treatment in type 2 diabetes mellitus: A randomized, double\u2010blind, placebo\u2010controlled, cross\u2010over trial (ENERGIZE)"],"prefix":"10.1111","volume":"25","author":[{"given":"Surya Panicker","family":"Rajeev","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences University of Liverpool  Liverpool UK"},{"name":"Liverpool University Hospitals NHS Foundation Trust University Hospital Aintree  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4275-601X","authenticated-orcid":false,"given":"Carl Alexander","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Psychology, Institute of Population Health University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences University of Liverpool  Liverpool UK"},{"name":"Liverpool University Hospitals NHS Foundation Trust University Hospital Aintree  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria S.","family":"Sprung","sequence":"additional","affiliation":[{"name":"Liverpool University Hospitals NHS Foundation Trust University Hospital Aintree  Liverpool UK"},{"name":"Research Institute for Sport and Exercise Sciences Liverpool John Moores University  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo A.","family":"Harrold","sequence":"additional","affiliation":[{"name":"Department of Psychology, Institute of Population Health University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C. 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