{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:57:42Z","timestamp":1789750662932,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To quantify the impact of foot complications on mortality outcomes in people with type 2 diabetes (T2D), and how routinely measured factors might modulate that risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Data for individuals with T2D for 2010\u20102020, from the Salford Integrated Care Record (Salford, UK), were extracted for laboratory and clinical data, and deaths. Annual expected deaths were taken from Office of National Statistics mortality data. An index of multiple deprivation (IMD) adjusted the standardized mortality ratio (SMR_IMD). Life years lost per death (LYLD) was estimated from the difference between expected and actual deaths.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 11\u2009806 T2D patients were included, with 5583 new diagnoses and 3921 deaths during 2010\u20102020. The number of expected deaths was 2135; after IMD adjustment, there were 2595 expected deaths. Therefore, excess deaths numbered 1326 (SMR_IMD 1.51). No foot complications were evident in\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099857. This group had an SMR_IMD of 1.13 and 2.74 LYLD. In total, 2979 patients had any foot complication recorded. In this group, the SMD_IMR was 2.29; of these, 2555 (75%) had only one foot complication. Patients with a foot complication showed little difference in percentage HbA1c more than 58\u2009mmol\/mol. In multivariate analysis, for those with a foot complication and an albumin\u2010to\u2010creatinine ratio of more than 3\u2009mg\/mmol, the odds ratio (OR) for death was 1.93, and for an estimated glomerular filtration rate of less than 60\u2009mL\/min\/1.73m\n                      <jats:sup>2<\/jats:sup>\n                      , the OR for death was 1.92.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with T2D but without a foot complication have an SMR_IMD that is only slightly higher than that of the general population. Those diagnosed with a foot complication have a mortality risk that is double that of those without T2D.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15260","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T21:43:51Z","timestamp":1695073431000},"page":"3662-3670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Diabetes foot complications and standardized mortality rate in type 2 diabetes"],"prefix":"10.1111","volume":"25","author":[{"given":"Mike","family":"Stedman","sequence":"first","affiliation":[{"name":"RES Consortium  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Salford Royal Foundation Trust  Salford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dunn","sequence":"additional","affiliation":[{"name":"East Cheshire Trust  Macclesfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernado","family":"Meza\u2010Torres","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Martin","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Salford Royal Foundation Trust  Salford UK"},{"name":"Department of Medicine University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil D.","family":"Reeves","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Faculty of Science and Engineering Manchester Metropolitan University  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Jude","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Feher","sequence":"additional","affiliation":[{"name":"Chelsea and Westminster Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry","family":"Rayman","sequence":"additional","affiliation":[{"name":"The Ipswich Diabetes Centre and Research Unit Ipswich Hospital NHS Trust  Ipswich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2897-2026","authenticated-orcid":false,"given":"Martin B.","family":"Whyte","sequence":"additional","affiliation":[{"name":"Diabetic Foot Clinic King's College Hospital Foundation Trust  London UK"},{"name":"Faculty of Health and Medical Sciences University of Surrey  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Edmonds","sequence":"additional","affiliation":[{"name":"Diabetic Foot Clinic King's College Hospital Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9537-4050","authenticated-orcid":false,"given":"Adrian H.","family":"Heald","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Salford Royal Foundation Trust  Salford UK"},{"name":"Department of Medicine University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_9_3_1","volume-title":"Endotext","author":"Boulton AJM","year":"2000"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17\u20101836"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14151"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08\u20101242"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010017\u20104522\u2010x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7125.100"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002942"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.12.018"},{"key":"e_1_2_9_11_1","unstructured":"NHS Digital.Quality and Outcomes Framework. 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