{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:08:05Z","timestamp":1784171285304,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PCEGP3_186978"],"award-info":[{"award-number":["PCEGP3_186978"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To provide a preliminary evaluation of the accuracy and safety of Gluclas decision support system suggestions in a hypoglycaemic clamp study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This analysis was performed using data from 32 participants (four groups with different glucose\u2010insulin regulation: post Roux\u2010en\u2010Y gastric bypass with and without postprandial hypoglycaemia syndrome, postsleeve gastrectomy and non\u2010operated controls) undergoing Gluclas\u2010assisted hypoglycaemic clamps (target: 2.5\u2009mmol\/L for 20\u2009minutes at 150\u2009minutes after oral glucose ingestion). Gluclas provided glucose infusion rate suggestions upon manual entry of blood glucose values (every 5\u2009minutes), which were either followed or overruled by investigators after critical review. Accuracy and safety were evaluated by mean absolute error (MAE), mean absolute percentage error (MAPE), average glucose level, coefficient of variation (CV) and minimal glucose level during the 20\u2010minute hypoglycaemic period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Investigators accepted 84% of suggestions, with a mean deviation of 30.33\u2009mg\/min. During the hypoglycaemic period, the MAE was 0.16 (0.12\u20100.24) (median [interquartile range]) mmol\/L and the MAPE was 6.12% (4.80%\u20109.29%). CV was 4.90% (3.58%\u20107.27%), with 5% considered the threshold for sufficient quality. The minimal glucose level was 2.40 (2.30\u20102.50) mmol\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gluclas achieved sufficiently high accuracy with minimal safety risks in a population with differences in glucose\u2010insulin dynamics, underscoring its applicability to various patient groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15265","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T04:23:23Z","timestamp":1694147003000},"page":"3709-3715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical evaluation of a decision support system for glucose infusion in hypoglycaemic clamp experiments"],"prefix":"10.1111","volume":"25","author":[{"given":"Jacopo","family":"Pavan","sequence":"first","affiliation":[{"name":"Department of Information Engineering University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Herzig","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6096-0009","authenticated-orcid":false,"given":"Afrodity","family":"Tripyla","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4908-0596","authenticated-orcid":false,"given":"Chiara","family":"Dalla Man","sequence":"additional","affiliation":[{"name":"Department of Information Engineering University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1993-7672","authenticated-orcid":false,"given":"Lia","family":"Bally","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital Bern University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8214-2752","authenticated-orcid":false,"given":"Simone","family":"Del Favero","sequence":"additional","affiliation":[{"name":"Department of Information Engineering University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-2-374"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.3.278"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl175"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-865637"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2339"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118839"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198806093182302"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296815576957"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996224"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4126"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296821991514"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2022.107104"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05861-9"},{"key":"e_1_2_10_15_1","unstructured":"[Online]. Available:https:\/\/github.com\/jp993\/gluclas."},{"key":"e_1_2_10_16_1","unstructured":"[Online]. Available:https:\/\/github.com\/jp993\/gluclas_dev."},{"key":"e_1_2_10_17_1","unstructured":"European Medicines Agency.Guideline on non\u2010clinical and clinical development of similar biological medicinal products containing recombinant human insulin and insulin analogues. 03 11 2022. [Online]. Available:https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-non-clinical-clinical-development-similar-biological-medicinal-products-containing_en-0.pdf"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05361-8"},{"key":"e_1_2_10_19_1","volume-title":"Proceedings of the 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)","author":"Pavan J","year":"2021"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:53:04Z","timestamp":1761861184000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/dom.15265"],"URL":"https:\/\/doi.org\/10.1111\/dom.15265","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,8]]},"assertion":[{"value":"2023-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}