{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:25:00Z","timestamp":1790814300482,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To characterize the pharmacokinetic and pharmacodynamic properties of once\u2010weekly insulin icodec in type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In an open\u2010label trial, 46 individuals with T2D (18\u201075\u2009years; body mass index 18.0\u201038.0\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; glycated haemoglobin \u226475\u2009mmol\/mol [\u22649%]; basal insulin\u2010treated) received subcutaneous once\u2010weekly icodec for \u22658\u2009weeks at individualized doses, aiming at a pre\u2010breakfast plasma glucose concentration of 4.4 to 7.0\u2009mmol\/L (80\u2010126\u2009mg\/dL) on the last three mornings of each weekly dosing interval. Frequent blood sampling to assess total serum icodec concentration (ie, albumin\u2010bound and unbound) occurred from first icodec dose until 35\u2009days after last dose. Icodec trough concentrations following initiation of once\u2010weekly dosing were predicted by pharmacokinetic modelling. During the final 3\u2009weeks of icodec treatment, while at steady state, the icodec glucose\u2010lowering effect was assessed in three glucose clamps (target 7.5\u2009mmol\/L [135\u2009mg\/dL]): 0 to 36, 40 to 64 and 144 to 168\u2009h post\u2010dose, thus covering the initial, middle and last part of the 1\u2010week dosing interval. Glucose\u2010lowering effect during a complete dosing interval was predicted by pharmacokinetic\u2010pharmacodynamic modelling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Model\u2010predicted icodec steady state was attained after 3 to 4\u2009weeks. At steady state, model\u2010predicted daily proportions of glucose\u2010lowering effect on days 1 to 7 of the 1\u2010week dosing interval were 14.1%, 16.1%, 15.8%, 15.0%, 14.0%, 13.0% and 12.0%, respectively. Icodec duration of action was at least 1\u2009week in all participants. Once\u2010weekly icodec was overall safe and well tolerated in the current trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The pharmacokinetic and pharmacodynamic characteristics of icodec in individuals with T2D support its potential as a once\u2010weekly basal insulin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15266","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T07:10:28Z","timestamp":1694416228000},"page":"3716-3723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Pharmacokinetic and pharmacodynamic properties of once\u2010weekly insulin icodec in individuals with type 2 diabetes"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3554-0405","authenticated-orcid":false,"given":"Thomas R.","family":"Pieber","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine Medical University of Graz  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisse","family":"Asong","sequence":"additional","affiliation":[{"name":"Novo Nordisk  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Fluhr","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine Medical University of Graz  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"H\u00f6ller","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine Medical University of Graz  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels R.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Novo Nordisk  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas H.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Novo Nordisk  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Ribel\u2010Madsen","sequence":"additional","affiliation":[{"name":"Novo Nordisk  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Svehlikova","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine Medical University of Graz  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri","family":"Vinther","sequence":"additional","affiliation":[{"name":"Novo Nordisk  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarete","family":"Voortman","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology, Department of Internal Medicine Medical University of Graz  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Haahr","sequence":"additional","affiliation":[{"name":"Novo Nordisk  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S106821"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13132"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0819-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01327.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154924"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-021-01189-6"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14871"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00257"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002301"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2022474"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-2877"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-2878"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-191-OR"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(23)00093-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00520-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.11313"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2303208"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-022-01243-6"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296815576957"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/009286159502900324"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12703"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01638.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920010791636185"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14956"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-2396"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00388-6"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc22-2395"},{"key":"e_1_2_9_30_1","volume-title":"Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications","author":"Rowland M","year":"2011"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T21:53:32Z","timestamp":1761861212000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,11]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/dom.15266"],"URL":"https:\/\/doi.org\/10.1111\/dom.15266","archive":["Portico"],"relation":{},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,11]]},"assertion":[{"value":"2023-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}