{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:47:27Z","timestamp":1790722047424,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether combined treatment with empagliflozin (a sodium\u2010glucose cotransporter\u20102 inhibitor) and semaglutide (a glucagon\u2010like peptide\u20101 receptor agonist) can reduce urinary albumin\u2010creatinine ratio (UACR) compared to treatment with empagliflozin alone in individuals with type 2 diabetes (T2D) and albuminuria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a randomized, placebo\u2010controlled, double\u2010blind, parallel study including 60 individuals with T2D and albuminuria. All participants initiated open\u2010label empagliflozin 25 mg once daily, on top of renin\u2010angiotensin system inhibition, in a run\u2010in period of 26\u2009weeks. Subsequently, participants were randomized to semaglutide or placebo 1 mg once weekly for 26\u2009weeks. The primary endpoint was change in UACR. Secondary endpoints were change in: (i) measured glomerular filtration rate (GFR); (ii) 24\u2010hour systolic blood pressure; (iii) glycated haemoglobin (HbA1c) level; (iv) body weight; and (v) plasma renin and aldosterone levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Addition of semaglutide to empagliflozin provided no additional change in UACR from randomization to end\u2010of\u2010treatment. The mean (95% confidence interval) difference in UACR was \u201322 (\u201344; 10)% (\n                      <jats:italic>P =<\/jats:italic>\n                      0.15) between treatment groups. Neither GFR, 24\u2010hour blood pressure, body weight, nor plasma renin activity was changed with semaglutide. HbA1c (\u20138 [\u201313; \u20133] mmol\/mol;\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.003) and plasma aldosterone (\u201330 [\u201350; \u20133] pmol\/L;\n                      <jats:italic>P<\/jats:italic>\n                      =\u20090.035) were reduced with semaglutide compared to placebo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Semaglutide added to empagliflozin did not change UACR, measured GFR, 24\u2010hour systolic blood pressure, body weight or plasma renin levels in individuals with T2D and albuminuria. Semaglutide improved glycaemic control and plasma aldosterone levels compared to placebo.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15287","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T21:47:15Z","timestamp":1695073635000},"page":"54-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Albuminuria\u2010lowering effect of adding semaglutide on top of empagliflozin in individuals with type 2 diabetes: A randomized and placebo\u2010controlled study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7520-2326","authenticated-orcid":false,"given":"Suvanjaa","family":"Sivalingam","sequence":"first","affiliation":[{"name":"Steno Diabetes Center Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor 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