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Participants underwent oral glucose tolerance test (OGTT) and isoglycaemic intravenous glucose infusion at baseline and at 52\u2009weeks, and an additional OGTT after the drug wash\u2010out.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 104 women [age: mean\u2009\u00b1\u2009SD, 38\u2009\u00b1\u20095\u2009years; fasting plasma glucose (FPG): 5.5\u2009\u00b1\u20090.4\u2009mmol\/L; glycated haemoglobin (HbA1c): 33\u2009\u00b1\u20094\u2009mmol\/mol, bodyweight: 88.2\u2009\u00b1\u200914.8\u2009kg, body mass index: 31.1\u2009\u00b1\u20094.3\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ] were assigned to liraglutide (n\u2009=\u200949) or placebo (n\u2009=\u200955). Estimated treatment difference (ETD) for area under curve during OGTT was \u2212173 (95% confidence interval \u2212250 to \u221297) mmol\/L\u2009\u00d7\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001, but after wash\u2010out the difference disappeared [ETD 58 (\u221230 to 146) mmol\/L\u2009\u00d7\u2009min,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.536]. Liraglutide reduced FPG [ETD \u22120.2 (\u22120.4 to \u22120.1) mmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.018], HbA1c [\u22122.2 (\u22123.5 to \u22120.8) mmol\/mol,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.018] and bodyweight [\u22123.9 (\u22126.2 to \u22121.6) kg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.012]. No change in the incretin effect was observed. The number of women with prediabetes was reduced from 64% to 10% with liraglutide vs. 50% with placebo [adjusted odds ratio 0.10 (0.03\u20100.32),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Treatment with liraglutide for 52\u2009weeks improved glucose tolerance, FPG, HbA1c and bodyweight in women with overweight\/obesity and pGDM. Progression to prediabetes while on drug was markedly reduced, but after a 1\u2010week drug wash\u2010out, the effect was lost.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15306","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T04:37:20Z","timestamp":1697517440000},"page":"201-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Liraglutide treatment for the prevention of glucose tolerance deterioration in women with prior gestational diabetes mellitus: A 52\u2010week randomized controlled clinical trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1600-3145","authenticated-orcid":false,"given":"Signe","family":"Foghsgaard","sequence":"first","affiliation":[{"name":"Clinical Research, Steno Diabetes Center Copenhagen University of Copenhagen  Herlev Denmark"},{"name":"Department of Gynaecology and Obstetrics, Herlev 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