{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:20Z","timestamp":1772160140484,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1042231"],"award-info":[{"award-number":["1042231"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1126886"],"award-info":[{"award-number":["1126886"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["513781"],"award-info":[{"award-number":["513781"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the relationships between glycaemia and treatment complexity over 6\u2009years in well\u2010characterized community\u2010based people with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Fremantle Diabetes Study Phase II participants who had type 2 diabetes with glycated haemoglobin (HbA1c) and blood glucose\u2010lowering therapy (BGLT) data over 6\u2009years were included. Group\u2010based multi\u2010trajectory modelling identified combined HbA1c\/BGLT trajectory subgroups for diabetes durations of \u22641.0\u2009year (Group 1; n\u2009=\u2009160), &gt;1.0 to 10.0\u2009years (Group 2; n\u2009=\u2009382;) and\u2009&gt;10.0\u2009years (Group 3; n\u2009=\u2009357). Multinomial regression was used to identify baseline associates of subgroup membership.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The optimum numbers of trajectory subgroups were three in Group 1 (low, medium, high) and four in Groups 2 and 3 (low, low\/high medium, high). Each low trajectory subgroup maintained a mean HbA1c\u2009concentration of &lt;53\u2009mmol\/mol (&lt;7.0%) on lifestyle measures, or monotherapy (Group 3). All five medium subgroups had stable HbA1c trajectories at &lt;58\u2009mmol\/mol (&lt;7.5%) but required increasing oral BGLT, or insulin (Group 3, high medium). The Group 1 high subgroup showed a falling then increasing HbA1c with steady progression to insulin. The high subgroups in Groups 2 and 3 showed stable HbA1c profiles at means of approximately 64\u2009mmol\/mol (8.0%) and 86\u2009mmol\/L (10.0%), respectively, on insulin. Non\u2010Anglo Celt ethnicity, central obesity and hypertriglyceridaemia were strongly associated with Group 1 high subgroup membership. Younger age at diagnosis and central obesity were independent associates of the most adverse HbA1c trajectories in Groups 2 and 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data demonstrate diabetes duration\u2010dependent heterogeneity in glycaemic and treatment profiles and related clinical and laboratory variables, which have implications for management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15314","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:44:59Z","timestamp":1696484699000},"page":"283-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The relationship between glycated haemoglobin and blood glucose\u2010lowering treatment trajectories in type 2 diabetes: The Fremantle Diabetes Study Phase\n                    <scp>II<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-7411","authenticated-orcid":false,"given":"Timothy M. E.","family":"Davis","sequence":"first","affiliation":[{"name":"University of Western Australia, Medical School, Fremantle Hospital  Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Western Australia, Medical School, Fremantle Hospital  Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802743"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12655"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S006"},{"issue":"4","key":"e_1_2_10_7_1","first-page":"592","article-title":"Management trajectories in the type 2 diabetes integrated delivery system project in Taiwan: accounting for behavioral therapy, nutrition education and therapeutics","volume":"23","author":"Chang HY","year":"2014","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.08.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-014-0633-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys065"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039504"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0225"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.03.06.dc05-1567"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH080766"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.121208.131413"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13792"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14103"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510579"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(02)00191-5"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v7.i3.34"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000241"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.10.003"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12953"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-018-1069-2"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-018-3692-z"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.3.204"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12696"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006407"},{"key":"e_1_2_10_29_1","volume-title":"Appropriate use of SGLT2s and GLP\u20101RAs with insulin to reduce CVD risk in patients with diabetes","author":"Patel R","year":"2023"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30051-2"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05741-2"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2524.2010.00972.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1348"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T02:32:11Z","timestamp":1761877931000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,5]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/dom.15314"],"URL":"https:\/\/doi.org\/10.1111\/dom.15314","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15314\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15314\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15314\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15314\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15314\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15314\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,5]]},"assertion":[{"value":"2023-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}