{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:21Z","timestamp":1772160141023,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T00:00:00Z","timestamp":1699747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the efficacy of artificial pancreas systems (APS) use among pregnant women with type 1 diabetes mellitus (T1DM) by conducting a meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched five databases, including EMBASE, Web of Science, PubMed, Cochrane Library and SCOPUS, for literature on APS use among pregnant women with T1DM before October 9, 2023. The primary endpoint was 24\u2010hour time in range (TIR; 3.5\u20107.8 mmol\/L). Secondary endpoints included glycaemic metrics for 24\u2010hour (mean blood glucose [MBG], time above range [TAR], time below range [TBR]), and overnight TIR and TBR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified four randomized controlled trials involving 164 participants; one study with 16 participants focused on overnight APS use, and the other three focused on 24\u2010hour APS use. Compared with standard care, APS exhibited a favourable effect on 24\u2010hour TIR (standard mean difference [SMD]\u2009=\u20090.53, 95% confidence interval [CI] 0.25, 0.80,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), overnight TIR (SMD\u2009=\u20090.67, 95% CI 0.39, 0.95,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and overnight TBR (&lt;3.5 mmol\/L; SMD\u2009=\u2009\u22120.49, 95% CI \u22120.77, \u22120.21\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), while there was no significant difference in 24\u2010hour TAR, 24\u2010hour TBR, or MBG between the two groups. We further conducted subgroup analyses after removing the trial focused on overnight APS use and showed that 24\u2010hour APS use reduced not only the 24\u2010hour TIR (SMD\u2009=\u20090.41, 95% CI 0.12, 0.71;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.007) but also the 24\u2010hour TBR (&lt;2.8 mmol\/L; SMD\u2009=\u2009\u22120.77, 95% CI \u22121.32, \u22120.23,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that APS might improve 24\u2010hour TIR and overnight glycaemic control, and 24\u2010hour APS use also significantly reduced 24\u2010hour TBR (2.8 mmol\/L) among pregnant women with T1DM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15357","type":"journal-article","created":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:24:50Z","timestamp":1699827890000},"page":"673-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of artificial pancreas system use on glycaemic control among pregnant women with type 1 diabetes mellitus: A meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7062-0147","authenticated-orcid":false,"given":"Mengyun","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danrui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9889-5812","authenticated-orcid":false,"given":"Ping","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaofan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 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