{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:30:58Z","timestamp":1791873058829,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the efficacy and safety of beinaglutide as an adjunct to lifestyle intervention among non\u2010diabetic Chinese individuals with overweight or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This multicentre, randomized, double\u2010blind, placebo\u2010controlled trial (ChiCTR1900023428) included 427 Chinese adults with a body mass index of 28 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      or higher (obesity) or 24\u201027.9\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (overweight) with weight\u2010related complications. Patients were randomized in a 2:1 ratio to receive 0.2\u2009mg of beinaglutide (subcutaneous) thrice daily or placebo for 16\u2009weeks. Co\u2010primary endpoints were body weight change and the proportion of patients with a weight reduction of 5% or more.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean body weight change from baseline to week 16 was \u22126.0% and \u22122.4% in the beinaglutide (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009282) and placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009138) groups, respectively; the mixed model repeated measures difference was \u22123.6% (95% confidence interval: \u22124.6% to \u22122.6%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001). At week 16, more beinaglutide\u2010treated patients achieved a weight reduction of 5% or more (58.2% vs. 25.4% [placebo], odds ratio: 4.4;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001) and\u2009of\u200910% or more (21.3% vs. 5.1% [placebo], odds ratio: 5.5;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.0001). Beinaglutide also resulted in greater waist circumference reduction (difference: \u22121.81\u2009cm;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01). The weight regain rate 12\u2009weeks after beinaglutide treatment was 0.78%. Nausea (transient and mild\u2010to\u2010moderate) was the most common adverse event in the beinaglutide group (49.3% vs. 7.1% [placebo]). More patients receiving beinaglutide discontinued treatment because of adverse events (5.9% vs. 0.7% [placebo]). Pancreatitis or an increased resting heart rate was not observed in the beinaglutide group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Beinaglutide combined with lifestyle intervention resulted in significant and clinically meaningful weight reduction with good tolerance in non\u2010diabetic Chinese individuals with overweight or obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15360","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T22:45:50Z","timestamp":1699569950000},"page":"690-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Beinaglutide for weight management in Chinese individuals with overweight or obesity: A phase 3 randomized controlled clinical study"],"prefix":"10.1111","volume":"26","author":[{"given":"Kang","family":"Chen","sequence":"first","affiliation":[{"name":"The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Shan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixia","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University  Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Qu","sequence":"additional","affiliation":[{"name":"Shanghai Tenth People's Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2503-7534","authenticated-orcid":false,"given":"Guijun","family":"Qin","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3961-9321","authenticated-orcid":false,"given":"Xuefeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiquan","family":"Xin","sequence":"additional","affiliation":[{"name":"Shanghai Benemae Pharmaceutical Corporation  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3009-6033","authenticated-orcid":false,"given":"Tsung\u2010han","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Shanghai Benemae Pharmaceutical Corporation  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-3540","authenticated-orcid":false,"given":"Yiming","family":"Mu","sequence":"additional","affiliation":[{"name":"The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5476454"},{"key":"e_1_2_11_3_1","unstructured":"World Health Organization.Health Topics: Obesity overview.2023.https:\/\/www.who.int\/health-topics\/obesity#tab=tab_1. 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