{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:33:14Z","timestamp":1791228794151,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study evaluated the safety and efficacy of a moderate\u2010intensity statin with ezetimibe combination therapy versus high\u2010intensity statin monotherapy in patients with metabolic syndrome (MetS) and atherosclerotic cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this post\u2010hoc subgroup analysis of the RACING trial, patients were analysed based on the presence of MetS. MetS was defined as meeting at least three of the five following criteria: (a) elevated waist circumference; (b) elevated triglycerides; (c) reduced high\u2010density lipoprotein cholesterol; (d) elevated blood pressure; and (e) elevated fasting glucose. The primary outcome was a 3\u2010year composite of cardiovascular death, major cardiovascular events, or non\u2010fatal stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 3780 patients enrolled in the RACING trial, 1703 (45.1%) had MetS at baseline. The primary outcome rate was 10.1% and 10.3% in patients with MetS receiving ezetimibe combination therapy versus high\u2010intensity statin monotherapy (hazard ratio\u2009=\u20090.97; 95% confidence interval\u2009=\u20090.72\u20101.32;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.868). Lower rates of intolerance\u2010related drug discontinuation or dose reduction (3.9% vs. 8.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) and lower low\u2010density lipoprotein cholesterol levels (57 vs. 65\u2009mg\/dl;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) were observed with ezetimibe combination therapy versus high\u2010intensity statin monotherapy. Furthermore, the rate of new\u2010onset diabetes was 18.5% and 19.1% in each group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.822). There were no significant interactions between MetS and therapy regarding study outcomes in the total population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with MetS and atherosclerotic cardiovascular disease, a moderate\u2010intensity statin with ezetimibe combination therapy had comparable cardiovascular benefits with those of high\u2010intensity statin monotherapy. Meanwhile, ezetimibe combination therapy was associated with lower drug intolerance and low\u2010density lipoprotein cholesterol levels, but there was no apparent between\u2010group difference in new\u2010onset diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15374","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T19:09:55Z","timestamp":1700852995000},"page":"829-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Moderate\u2010intensity statin with ezetimibe combination therapy versus high\u2010intensity statin monotherapy in patients with metabolic syndrome and atherosclerotic cardiovascular disease: A post\u2010hoc analysis of the\n                    <scp>RACING<\/scp>\n                    trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4526-6120","authenticated-orcid":false,"given":"Yong\u2010Joon","family":"Lee","sequence":"first","affiliation":[{"name":"Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7667-0199","authenticated-orcid":false,"given":"Sang\u2010Hyup","family":"Lee","sequence":"additional","affiliation":[{"name":"Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-6399","authenticated-orcid":false,"given":"Seng Chan","family":"You","sequence":"additional","affiliation":[{"name":"Department of Biomedical Systems Informatics Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-4942","authenticated-orcid":false,"given":"Yong\u2010ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9201-4818","authenticated-orcid":false,"given":"Seung\u2010Jun","family":"Lee","sequence":"additional","affiliation":[{"name":"Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-039X","authenticated-orcid":false,"given":"Sung\u2010Jin","family":"Hong","sequence":"additional","affiliation":[{"name":"Severance Hospital Yonsei University College of Medicine  Seoul South 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