{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:36:40Z","timestamp":1793144200988,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess whether oral semaglutide provides better glycaemic control, compared with dipeptidyl peptidase\u20104 inhibitor (DPP\u20104i) continuation, in people with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In this multicentre, open\u2010label, prospective, randomized, parallel\u2010group comparison study, participants receiving DPP\u20104is were either switched to oral semaglutide (3\u201014\u2009mg\/day) or continued on DPP\u20104is. The primary endpoint was the change in glycated haemoglobin (HbA1c) over 24\u2009weeks. Secondary endpoints included changes in metabolic parameters and biomarkers, along with the occurrence of adverse events. Factors associated with HbA1c improvement were also explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 174 eligible participants were enrolled; 17 dropped out of the study. Consequently, 82 participants in the DPP\u20104i group and 75 participants in the semaglutide group completed the study and were included in the analysis. Improvement in HbA1c at week 24 was significantly greater when switching to semaglutide compared with DPP\u20104i continuation [\u22120.65 (95% confidence interval: \u22120.79, \u22120.51) vs. +0.05 (95% confidence interval: \u22120.07, 0.16) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001)]. Body weight, lipid profiles and liver enzymes were significantly improved in the semaglutide group than in the DPP\u20104i continuation group. Multiple linear regression analysis revealed that baseline HbA1c and homeostasis model assessment 2\u2010R were independently associated with HbA1c improvement after switching to semaglutide. Seven participants in the semaglutide group discontinued medication because of gastrointestinal symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although the potential for gastrointestinal symptoms should be carefully considered, switching from DPP\u20104is to oral semaglutide may be beneficial for glycaemic control and metabolic abnormalities in people with higher HbA1c and insulin resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15393","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T03:35:26Z","timestamp":1702265726000},"page":"961-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Glycaemic control efficacy of switching from dipeptidyl peptidase\u20104 inhibitors to oral semaglutide in subjects with type 2 diabetes: A multicentre, prospective, randomized, open\u2010label, parallel\u2010group comparison study (\n                    <scp>SWITCH\u2010SEMA<\/scp>\n                    2 study)"],"prefix":"10.1111","volume":"26","author":[{"given":"Sho","family":"Furusawa","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0713-221X","authenticated-orcid":false,"given":"Hiroshi","family":"Nomoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Jiyugaoka Medical Clinic  Obihiro Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Medicine Hakodate Central General Hospital  Hakodate Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aika","family":"Miya","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiraku","family":"Kameda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu Yong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Sapporo Diabetes and Thyroid Clinic  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So","family":"Nagai","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Medicine Sapporo Medical Center, NTT East Corporation  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Taneda","sequence":"additional","affiliation":[{"name":"Diabetes Center Manda Memorial Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Kurihara Clinic  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akinobu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Atsumi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"SWITCH\u2010SEMA 2 study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30104-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706245"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30327-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13960"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.2.271"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.10.1711"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401145"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.123"},{"key":"e_1_2_9_11_1","article-title":"Glucagon\u2010like peptide analogues for type 2 diabetes mellitus","volume":"2011","author":"Shyangdan DS","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-014-0061-3"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00178"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_9_15_1","first-page":"891","article-title":"Semaglutide and cardiovascular outcomes in patients with type 2 Diabetes","volume":"376","author":"Marso SP","year":"2017","journal-title":"N Engl J Med"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31149-3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0034"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13340-022-00605-x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2827-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14998"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100387"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2942"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-056885"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12913"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30194-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13899"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7258.405"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2023.110599"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.08.016"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ12-0158"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012226"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0749"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0883"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001649"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2013.10.003"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0371"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:23:19Z","timestamp":1761866599000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,11]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/dom.15393"],"URL":"https:\/\/doi.org\/10.1111\/dom.15393","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15393\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v1\/review6","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v1\/review5","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v1\/review8","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v2\/review5","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v2\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v1\/review7","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v1\/review9","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15393\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,11]]},"assertion":[{"value":"2023-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}