{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:31:44Z","timestamp":1783960304663,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine the real\u2010world efficacy of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) in monogenic obesity in patients with Alstr\u00f6m syndrome (ALMS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We screened 72 UK adult patients with ALMS and offered treatment to 34 patients meeting one of the following criteria: body mass index of 25 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      or higher, insulin resistance, suboptimal glycaemic control on antihyperglycaemic medications or non\u2010alcoholic fatty liver disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 30 patients, with a mean age of 31\u2009\u00b1\u200911\u2009years and a male to\u2010female ratio of 2:1, completed 6\u2009months of treatment with GLP\u20101 RAs either in the form of semaglutide or exenatide. On average, treatment with GLP\u20101 RAs reduced body weight by 5.4\u2009\u00b1\u20091.7\u2009(95% confidence interval [CI] 3.6\u20107) kg and HbA1c by 12\u2009\u00b1\u20093.3\u2009(95% CI 8.7\u201015.3) mmol\/mol, equating to 6% weight loss (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01) and 1.1% absolute reduction in HbA1c (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01). Significant improvements were also observed in serum total cholesterol, triglycerides, low\u2010density lipoprotein cholesterol, high\u2010density lipoprotein cholesterol and alanine aminotransferase. The improvement of metabolic variables in our cohort of monogenic syndromic obesity was comparable with data for polygenic obesity, irrespective of weight loss.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Data from our centre highlight the non\u2010inferiority of GLP\u20101 RAs in monogenic syndromic obesity to the available GLP\u20101 RA\u2010use data in polygenic obesity, therefore, these agents can be considered as a treatment option in patients with ALMS, as well as other forms of monogenic obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15398","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T02:23:50Z","timestamp":1703730230000},"page":"989-996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["<scp>G<\/scp>\n                    lucagon\u2010like peptide\u20101 analogues in monogenic syndromic obesity: Real\u2010world data from a large cohort of Alstr\u00f6m syndrome patients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6768-5495","authenticated-orcid":false,"given":"Sadaf","family":"Ali","sequence":"first","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"},{"name":"Institute of Metabolism and Systems Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanat","family":"Baig","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"},{"name":"Institute of Metabolism and Systems Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subadra","family":"Wanninayake","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"da Silva Xavier","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Dawson","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Paisey","sequence":"additional","affiliation":[{"name":"Torbay and South Devon NHS Foundation Trust  Torquay, Torbay UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3629-2338","authenticated-orcid":false,"given":"Tarekegn","family":"Geberhiwot","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust  Birmingham UK"},{"name":"Institute of Metabolism and Systems Research University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155217"},{"key":"e_1_2_9_3_1","unstructured":"IDF_Atlas_10th_Edition_2021.pdf [Internet]. 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