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We investigated body surface electroacupuncture stimulation (ES) at ST25 (targeted at the abdomen) induction of brown adipose thermogenesis and the neural mechanism of this process. Inguinal white adipose tissue (iWAT) and interscapular brown adipose tissue (iBAT) were collected and the thermogenic protein expression levels were measured to evaluate iBAT thermogenesis capacity. The thermogenic centre activating region and sympathetic outflow were evaluated based on neural electrical activity and c\u2010fos expression levels. iWAT sensory axon plasticity was analysed with whole\u2010mount adipose tissue imaging. ES activated the sympathetic nerves in iBAT and the c\u2010fos\u2010positive cells induced sympathetic outflow activation to the iBAT from the medial preoptic area (MPA), the dorsomedial hypothalamus (DM) and the raphe pallidus nucleus (RPA). iWAT denervation mice exhibited decreased c\u2010fos\u2010positive cells in the DM and RPA, and lower recombinant uncoupling orotein 1 peroxisome proliferator\u2010activated receptor, \u03b23\u2010adrenergic receptor, and tyrosine hydroxylase expression. Remodelling the iWAT sensory axons recovered the signal from the MPA to the RPA and induced iBAT thermogenesis. The sympathetic denervation attenuated sensory nerve density. ES induced sympathetic outflow from the thermogenetic centres to iBAT, which mediated thermogenesis. iWAT sensory axon remodelling induced the MPA\u2013DM\u2013RPA\u2013iBAT thermogenesis pathway.<\/jats:p>","DOI":"10.1111\/dom.15444","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T01:24:16Z","timestamp":1705454656000},"page":"1430-1442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Remodelling the inguinal adipose sensory system to switch on the furnace: Electroacupuncture stimulation induces brown adipose thermogenesis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8635-4659","authenticated-orcid":false,"given":"Mengjiang","family":"Lu","sequence":"first","affiliation":[{"name":"Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese Medicine  Nanjing 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