{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:21Z","timestamp":1772160141566,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009448","name":"Universit\u00e0 degli Studi della Campania Luigi Vanvitelli","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009448","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n To assess and compare the metabolic and vascular effectiveness of sodium\u2010glucose cotransporter 2 inhibitors (SGLT\u20102i) and dipeptidyl peptidase\u20104 inhibitors (DPP\u20104i) in the clinical practice of patients with type 2 diabetes in Italy.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n GIOIA is a 2\u2010year prospective, multicentre, quasi\u2010experimental study that enrolled patients with type 2 diabetes initiating SGLT\u20102i or DPP\u20104i for inadequate glycaemic control [glycated haemoglobin (HbA1c) >7%] between March 2018 and March 2021. The primary endpoints were changes in markers of organ damage [carotid intima\u2010media thickness (CIMT), albuminuria, myocardial function] and HbA1c from baseline to year 2.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total, 1150 patients were enrolled in the study (SGLT\u20102i n\u2009=\u2009580, DPP\u20104i n\u2009=\u2009570). Patients initiated on SGLT\u20102i were younger (about 6\u2009years) and heavier (about 11\u2009kg), had higher HbA1c level (1% more), more albuminuria and cardiovascular events (16% more) than patients initiated on DPP\u20104i. CIMT and echocardiographic parameters were not significantly different. Propensity score matching yielded two groups, each consisting of 155 patients with diabetes with similar baseline characteristics. Despite a significant similar reduction in HbA1c levels in both groups (\u22120.8%), more patients on SGLT\u20102i had regression of CIMT and albuminuria (22% and 10%, respectively,\n p<\/jats:italic>\n \u2009<\u2009.001 vs. DPP\u20104i); more patients on DPP\u20104i had progression of CIMT and albuminuria (23% and 28%, respectively,\n p<\/jats:italic>\n \u2009<\u2009.001 vs. SGLT\u20102i). Left ventricular ejection fraction improved slightly (3%,\n p<\/jats:italic>\n \u2009=\u2009.043) on SGLT\u20102i only.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In a real\u2010world setting, both SGLT\u20102i and DPP\u20104i improve glycaemic control persisting after 2\u2009years of treatment, with a robust effect on both CIMT and albuminuria regression for SGLT\u20102i as compared with DPP\u20104i in the propensity score matching.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.15451","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T02:48:45Z","timestamp":1705546125000},"page":"1492-1501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Two years with\n GIOIA<\/scp>\n \u2018Effects of gliflozins and gliptins on markers of cardiovascular damage in type 2 diabetes\u2019: A prospective, multicentre, quasi\u2010experimental study on sodium\u2010glucose cotransporter 2 and dipeptidyl peptidase\u20104 inhibitors in diabetes clinical practice"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6459-5854","authenticated-orcid":false,"given":"Miriam","family":"Longo","sequence":"first","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, Division of Endocrinology and Diabetes University of Campania \u2018Luigi Vanvitelli\u2019 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, Division of Endocrinology and Diabetes University of Campania \u2018Luigi Vanvitelli\u2019 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Scappaticcio","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, Division of Endocrinology and Diabetes University of Campania \u2018Luigi Vanvitelli\u2019 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4659-7546","authenticated-orcid":false,"given":"Maria Ida","family":"Maiorino","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, Division of Endocrinology and Diabetes University of Campania \u2018Luigi Vanvitelli\u2019 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-321X","authenticated-orcid":false,"given":"Giuseppe","family":"Bellastella","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, Division of Endocrinology and Diabetes University of Campania \u2018Luigi Vanvitelli\u2019 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Capuano","sequence":"additional","affiliation":[{"name":"Section of Pharmacology \u2018L. Donatelli\u2019, Department of Experimental Medicine University of Campania \u2018Luigi Vanvitelli\u2019, Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3652-5154","authenticated-orcid":false,"given":"Katherine","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, Division of Endocrinology and Diabetes University of Campania \u2018Luigi Vanvitelli\u2019 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9377-873X","authenticated-orcid":false,"given":"Dario","family":"Giugliano","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences, Division of Endocrinology and Diabetes University of Campania \u2018Luigi Vanvitelli\u2019 Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"International Diabetes Federation.Diabetes Atlas.2021Accessed 20th October 2023. 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