{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:12:03Z","timestamp":1787022723532,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong Province","doi-asserted-by":"publisher","award":["2023CXPTO12"],"award-info":[{"award-number":["2023CXPTO12"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170989"],"award-info":[{"award-number":["32170989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The liver is an important metabolic organ that governs glucolipid metabolism, and its dysfunction may cause non\u2010alcoholic fatty liver disease, type 2 diabetes mellitus, dyslipidaemia, etc. We aimed to systematic investigate the key factors related to hepatic glucose metabolism, which may be beneficial for understanding the underlying pathogenic mechanisms for obesity and diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Oral glucose tolerance test (OGTT) phenotypes and liver transcriptomes of BXD mice under chow and high\u2010fat diet conditions were collected from GeneNetwork. QTL mapping was conducted to pinpoint genomic regions associated with glucose homeostasis. Candidate genes were further nominated using a multi\u2010criteria approach and validated to confirm their functional relevance in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results demonstrated that plasma glucose levels in OGTT were significantly affected by both diet and genetic background, with six genetic regulating loci were mapped on chromosomes 1, 4, and 7. Moreover, TEAD1, MYO7A and NDUFC2 were identified as the candidate genes. Functionally, siRNA\u2010mediated TEAD1, MYO7A and NDUFC2 knockdown significantly decreased the glucose uptake and inhibited the transcription of genes related to insulin and glucose metabolism pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study contributes novel insights to the understanding of hepatic glucose metabolism, demonstrating the impact of TEAD1, MYO7A and NDUFC2 on mitochondrial function in the liver and their regulatory role in maintaining in glucose homeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15491","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T10:29:00Z","timestamp":1708597740000},"page":"1775-1788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>TEAD1<\/scp>\n                    ,\n                    <scp>MYO7A<\/scp>\n                    and\n                    <scp>NDUFC2<\/scp>\n                    are novel functional genes associated with glucose metabolism in\n                    <scp>BXD<\/scp>\n                    recombinant inbred population"],"prefix":"10.1111","volume":"26","author":[{"given":"Yingying","family":"Wu","sequence":"first","affiliation":[{"name":"The Second School of Clinical Medicine of Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yantai Affiliated Hospital of Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofei","family":"Duan","sequence":"additional","affiliation":[{"name":"Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"The University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh","family":"Bajpai","sequence":"additional","affiliation":[{"name":"The University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Yang","sequence":"additional","affiliation":[{"name":"Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Mi","sequence":"additional","affiliation":[{"name":"Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Tian","sequence":"additional","affiliation":[{"name":"Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglai","family":"Qi","sequence":"additional","affiliation":[{"name":"Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Xu","sequence":"additional","affiliation":[{"name":"Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9311-5265","authenticated-orcid":false,"given":"Xiao Dong","family":"Chi","sequence":"additional","affiliation":[{"name":"Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05731-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00188-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00249.2019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2020.101398"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076133"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi22-0004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00802"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12121223"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2022.05.014"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021074"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12121755"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2022.10.030"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13049"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13970"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00931-x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03390-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010159"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176275"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2019.1711360"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104536"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11121762"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12844"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-5-7"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.012"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2021.111230"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154352"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0189"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1518"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.582949"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.106.058537"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq728"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2848"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2017.10.016"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2016.10.014"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.810301"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00390-6"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2020.05.007"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399815666181204145806"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.1091757"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.09.019"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081231"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2012"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14577"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00421-w"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113196660675"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.5370"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i3.711"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.09.020"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1063"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00732.2019"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03579-8"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00459.2022"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101630"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.131"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00732-5"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00264.2020"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102249"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.032"},{"key":"e_1_2_9_60_1","first-page":"115","article-title":"The genetic dissection of Myo7a gene expression in the retinas of BXD mice","volume":"24","author":"Lu Y","year":"2018","journal-title":"Mol Vis"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24708"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-022-02448-7"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13260"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197068"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1687215"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-021-01343-5"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.101058"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1067801"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2337-2"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.03.017"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119457"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00481-w"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112976"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201586R"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14811"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T04:51:17Z","timestamp":1761886277000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,22]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/dom.15491"],"URL":"https:\/\/doi.org\/10.1111\/dom.15491","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15491\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15491\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15491\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15491\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15491\/v1\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,22]]},"assertion":[{"value":"2023-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}