{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:54:55Z","timestamp":1790456095277,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the efficacy and safety of pioglitazone compared to placebo when added to metformin plus dapagliflozin, a sodium\u2010glucose cotransporter\u20102 (SGLT2) inhibitor, for patients with type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>In a multicentre study, with a randomized, double\u2010blind, placebo\u2010controlled design, 249 Korean patients with T2DM suboptimally managed on metformin and dapagliflozin were assigned to receive either pioglitazone (15\u2009mg daily) or placebo for 24\u2009weeks, followed by a 24\u2010week pioglitazone extension. Primary outcomes included changes in glycated haemoglobin (HbA1c), with secondary outcomes assessing insulin resistance, adiponectin levels, lipid profiles, liver enzymes, body weight and waist circumference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Pioglitazone administration resulted in a significant reduction in HbA1c levels (from 7.80%\u2009\u00b1\u20090.72% to 7.27%\u2009\u00b1\u20090.82%) compared with placebo (from 7.79%\u2009\u00b1\u20090.76% to 7.69%\u2009\u00b1\u20090.86%, corrected mean difference: \u22120.42%\u2009\u00b1\u20090.08%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) at 24\u2009weeks. Additional benefits from pioglitazone treatment included enhanced insulin sensitivity, increased adiponectin levels, raised high\u2010density lipoprotein cholesterol levels and reduced liver enzyme levels, resulting in improvement in nonalcoholic fatty liver disease liver fat score. Despite no serious adverse events in either group, pioglitazone therapy was modestly but significantly associated with weight gain and increased waist circumference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adjunctive pioglitazone treatment in T2DM inadequately controlled with metformin and dapagliflozin demonstrates considerable glycaemic improvement, metabolic benefits, and a low risk of hypoglycaemia. These advantages must be weighed against the potential for weight gain and increased waist circumference.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15526","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T02:24:03Z","timestamp":1709259843000},"page":"2188-2198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["A multicentre, double\u2010blind, placebo\u2010controlled, randomized, parallel comparison, phase 3 trial to evaluate the efficacy and safety of pioglitazone add\u2010on therapy in type 2 diabetic patients treated with metformin and dapagliflozin"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4137-1671","authenticated-orcid":false,"given":"Soo","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Seoul National University College of Medicine Seoul National University Bundang 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