{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:58:27Z","timestamp":1789441107234,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004470","name":"Daewoong Pharmaceutical Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the long\u2010term safety and efficacy of enavogliflozin 0.3\u2009mg\/day added to metformin in patients with type 2 diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>After 24\u2009weeks of a randomized, double\u2010blind treatment period with enavogliflozin 0.3\u2009mg\/day (n\u2009=\u2009101) or dapagliflozin 10\u2009mg\/day (n\u2009=\u200999) added to metformin, all patients received enavogliflozin 0.3\u2009mg\/day plus metformin for an additional 28\u2009weeks during the open\u2010label extension period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010two patients continued enavogliflozin (maintenance group), and 77 were switched from dapagliflozin to enavogliflozin (switch group). All adverse drug reactions (ADR) were mild in severity. In the maintenance group, ADRs (cystitis and vaginal infection) were reported in two patients (2.44%) during 52\u2009weeks. In the switch group, ADR (hypoglycaemia) was reported in one patient (1.30%) during a 28\u2010week open\u2010label extension period. At week 52, glycated haemoglobin and fasting plasma glucose were significantly lower than at the baseline, by 0.85% and 29.08\u2009mg\/dl, respectively, in the maintenance group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001 for both), and by 0.81% and 32.77\u2009mg\/dl, respectively, in the switch group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001 for both). At week 52, 68.92% of patients from the maintenance group and 64.29% from the switch group achieved glycated haemoglobin &lt;7%. A significant increase in the urine glucose\u2010creatinine ratio was observed at week 52, by 58.81\u2009g\/g and 63.77\u2009g\/g in the maintenance and switch groups, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Enavogliflozin added to metformin was tolerated well for up to 52\u2009weeks and provided continual glycaemic control in type 2 diabetes mellitus, along with a significant increase in the urine glucose\u2010creatinine ratio.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15537","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T05:56:06Z","timestamp":1709877366000},"page":"2248-2256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A 52\u2010week efficacy and safety study of enavogliflozin versus dapagliflozin as an add\u2010on to metformin in patients with type 2 diabetes mellitus:\n                    <scp>ENHANCE\u2010M<\/scp>\n                    extension study"],"prefix":"10.1111","volume":"26","author":[{"given":"Tae Seo","family":"Sohn","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Uijeongbu St Mary's Hospital, College of Medicine The Catholic University of Korea  Uijeongbu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung\u2010Ah","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Nowon Eulji Medical Center Eulji University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Bundang Jesaeng Hospital  Seongnam South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-4992","authenticated-orcid":false,"given":"Byung\u2010Wan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5921-2989","authenticated-orcid":false,"given":"Suk","family":"Chon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Kyung Hee University Hospital  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7857-546X","authenticated-orcid":false,"given":"In\u2010Kyung","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Kyung Hee University Hospital at Gangdong  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-5706","authenticated-orcid":false,"given":"Eun\u2010Gyoung","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Hallym University Dongtan Sacred Heart Hospital  Hwaseong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Won","family":"Son","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St Mary's Hospital, College of Medicine The Catholic University of Korea  Bucheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JaeJin","family":"Na","sequence":"additional","affiliation":[{"name":"Clinical Development Center Daewoong Pharmaceutical Co. 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