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The currently recognized standard of therapy for DKD is blockade of the renin\u2010angiotensin system with angiotensin\u2010converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). However, unless utilized at a very early stage, monotherapy with these drugs in DKD will only prevent or slow the progression of DKD and will neither stabilize nor reverse the progression of DKD to renal decompensation. Recently, the addition of a sodium\u2010glucose cotransporter\u20102 inhibitor and\/or a mineralocorticoid receptor blocker to ACE inhibitors or ARBs has been clearly shown to further decelerate the decline in renal function. The use of glucagon\u2010like peptide\u20101 (GLP\u20101) agonists shown promise in decelerating the progression of DKD. Other drugs that may aid in the deceleration the progression of DKD are dipeptidyl peptidase\u20104 inhibitors, pentoxifylline, statins, and vasodilating beta blockers. Therefore, aggressive therapy with combinations of these drugs (stacking) should improve the preservation of renal function in DKD.<\/jats:p>","DOI":"10.1111\/dom.15559","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T05:48:50Z","timestamp":1711086530000},"page":"2046-2053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The potential for improved outcomes in the prevention and therapy of diabetic kidney disease through \u2018stacking\u2019 of drugs from different classes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-6126","authenticated-orcid":false,"given":"David S. 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