{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:15:31Z","timestamp":1791908131809,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n To describe the overall fat distribution patterns independent of body mass index (BMI) in participants with type 2 diabetes (T2D) in the SURPASS\u20103 MRI substudy by comparison with sex\u2010 and BMI\u2010matched virtual control groups (VCGs) derived from the UK Biobank imaging study at baseline and Week 52.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n For each study participant at baseline and Week 52 (\n N<\/jats:italic>\n \u2009=\u2009296), a VCG of \u2265150 participants with the same sex and similar BMI was identified from the UK Biobank imaging study (\n N<\/jats:italic>\n \u2009=\u200940\u2009172). Average visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (aSAT) and liver fat (LF) levels and the observed standard deviations (SDs; standardized normal\n z<\/jats:italic>\n \u2010scores:\n z<\/jats:italic>\n \u2010VAT,\n z<\/jats:italic>\n \u2010aSAT and\n z<\/jats:italic>\n \u2010LF) were calculated based on the matched VCGs. Differences in\n z<\/jats:italic>\n \u2010scores between baseline and Week 52 were calculated to describe potential shifts in fat distribution pattern independent of weight change.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Baseline fat distribution patterns were similar across pooled tirzepatide (5, 10 and 15\u2009mg) and insulin degludec (IDeg) arms. Compared with matched VCGs, SURPASS\u20103 participants had higher baseline VAT (mean [SD]\n z<\/jats:italic>\n \u2010VAT +0.42 [1.23];\n p<\/jats:italic>\n \u2009<\u20090.001) and LF (\n z<\/jats:italic>\n \u2010LF +1.24 [0.92];\n p<\/jats:italic>\n \u2009<\u20090.001) but similar aSAT (\n z<\/jats:italic>\n \u2010aSAT \u22120.13 [1.11];\n p<\/jats:italic>\n \u2009=\u20090.083). Tirzepatide\u2010treated participants had significant decreases in\n z<\/jats:italic>\n \u2010VAT (\u22120.18 [0.58];\n p<\/jats:italic>\n \u2009<\u20090.001) and\n z<\/jats:italic>\n \u2010LF (\u22120.54 [0.84];\n p<\/jats:italic>\n \u2009<\u20090.001) but increased\n z<\/jats:italic>\n \u2010aSAT (+0.11 [0.50];\n p<\/jats:italic>\n \u2009=\u20090.012). Participants treated with IDeg had a significant change in\n z<\/jats:italic>\n \u2010LF only (\u22120.46 [0.90];\n p<\/jats:italic>\n \u2009=\u20090.001), while no significant changes were observed for\n z<\/jats:italic>\n \u2010VAT (+0.13 [0.52];\n p<\/jats:italic>\n \u2009=\u20090.096) and\n z<\/jats:italic>\n \u2010aSAT (+0.09 [0.61];\n p<\/jats:italic>\n \u2009=\u20090.303).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this exploratory analysis, treatment with tirzepatide in people with T2D resulted in a significant reduction of\n z<\/jats:italic>\n \u2010VAT and\n z<\/jats:italic>\n \u2010LF, while\n z<\/jats:italic>\n \u2010aSAT was increased from an initially negative value, suggesting a possible treatment\u2010related shift towards a more balanced fat distribution pattern with prominent VAT and LF loss.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/dom.15566","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T03:09:37Z","timestamp":1711422577000},"page":"2446-2455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effect of tirzepatide on body fat distribution pattern in people with type 2 diabetes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-8040","authenticated-orcid":false,"given":"Bertrand","family":"Cariou","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, CHU Nantes, CNRS, INSERM, l'institut du thorax Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Linge","sequence":"additional","affiliation":[{"name":"AMRA Medical AB Link\u00f6ping Sweden"},{"name":"Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Neeland","sequence":"additional","affiliation":[{"name":"University Hospitals Harrington Heart & Vascular Institute University Hospitals Cleveland Medical Center, and Case Western Reserve University School of Medicine Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Dahlqvist Leinhard","sequence":"additional","affiliation":[{"name":"AMRA Medical AB Link\u00f6ping Sweden"},{"name":"Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Petersson","sequence":"additional","affiliation":[{"name":"AMRA Medical AB Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0969-6214","authenticated-orcid":false,"given":"Laura","family":"Fern\u00e1ndez Land\u00f3","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Bray","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8721-9539","authenticated-orcid":false,"given":"\u00c1ngel","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"142","article-title":"The epidemic of obesity and diabetes: trends and treatments","volume":"38","author":"Barnes AS","year":"2011","journal-title":"Tex Heart Inst J"},{"key":"e_1_2_10_3_1","unstructured":"SoansR.How obesity and diabetes are linked. 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