{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:24:15Z","timestamp":1790223855937,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011920"],"award-info":[{"award-number":["2022A1515011920"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011730"],"award-info":[{"award-number":["2023A1515011730"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900379"],"award-info":[{"award-number":["81900379"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970683"],"award-info":[{"award-number":["81970683"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170457"],"award-info":[{"award-number":["82170457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371573"],"award-info":[{"award-number":["82371573"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the association between cardiovascular health metrics defined by Life's Essential 8 (LE8) scores and vascular complications among individuals with type 2 diabetes (T2D).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This prospective study included 11\u2009033 participants with T2D, all devoid of macrovascular diseases (including cardiovascular and peripheral artery disease) and microvascular complications (e.g. diabetic retinopathy, neuropathy and nephropathy) at baseline from the UK Biobank. The LE8 score comprised eight metrics: smoking, body mass index, physical activity, non\u2010high\u2010density lipoprotein cholesterol, blood pressure, glycated haemoglobin, diet and sleep duration. Cox proportional hazards models were established to assess the associations of LE8 scores with incident macrovascular and microvascular complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median follow\u2010up of 12.1\u2009years, we identified 1975 cases of incident macrovascular diseases and 1797 cases of incident microvascular complications. After adjusting for potential confounders, each 10\u2010point increase in the LE8 score was associated with an 18% lower risk of macrovascular diseases and a 15% lower risk of microvascular complications. Comparing individuals in the highest and lowest quartiles of LE8 scores revealed hazard ratios of 0.55 (95% confidence interval 0.47\u20100.62) for incident macrovascular diseases, and 0.61 (95% confidence interval 0.53\u20100.70) for incident microvascular complications. This association remained robust across a series of sensitivity analyses and nearly all subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher LE8 scores were associated with a lower risk of incident macrovascular and microvascular complications among individuals with T2D. These findings underscore the significance of adopting fundamental strategies to maintain optimal cardiovascular health and curtail the risk of developing diabetic vascular complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15583","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T06:19:14Z","timestamp":1711952354000},"page":"2673-2683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cardiovascular health metrics defined by\n                    <scp>Life's Essential<\/scp>\n                    8 scores and subsequent macrovascular and microvascular complications in individuals with type 2 diabetes: A prospective cohort study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6091-5964","authenticated-orcid":false,"given":"Ze\u2010Gui","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"You","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo\u2010Chao","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Biao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da\u2010Chuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5827-7876","authenticated-orcid":false,"given":"Jing\u2010Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang\u2010Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-6863","authenticated-orcid":false,"given":"Pin\u2010Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01301-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2022.101389"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi20-0030"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60484-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v12.i6.827"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-0072"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/db19-1046"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03700417"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-S005"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12122"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac264"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001078"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2023.01.021"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2022.101540"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02824-8"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.029441"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60404-8"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162388"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-1933"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.01.036"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/syt100"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwad033"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.2499"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3276"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.025252"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi17-0044"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004135"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.52239"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2022.101370"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.05.049"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01447-2"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.02.030"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07019-6"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399817666210309104203"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2007.00670.x"},{"issue":"18","key":"e_1_2_11_39_1","first-page":"1682","article-title":"Diet and kidney disease in high\u2010risk individuals with type 2 diabetes mellitus","volume":"173","author":"Dunkler D","year":"2013","journal-title":"JAMA Intern Med"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2810-z"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-021-02011-7"}],"updated-by":[{"DOI":"10.1111\/dom.15806","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000}}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:10:38Z","timestamp":1761869438000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/dom.15583"],"URL":"https:\/\/doi.org\/10.1111\/dom.15583","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15583\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15583\/v1\/review5","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15583\/v1\/review6","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15583\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15583\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15583\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15583\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15583\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15583\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15583\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2024-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}