{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:17:36Z","timestamp":1777414656946,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To create and validate a prediction model to identify patients with type 2 diabetes (T2D) at high risk of new\u2010onset heart failure (HF), including those treated with a sodium\u2010glucose cotransporter\u20102 (SGLT2) inhibitor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prediction model was developed from the Aliskiren Trial in Type 2 Diabetes Using Cardiorenal Endpoints (ALTITUDE), a trial in T2D patients with albuminuria or cardiovascular disease. We included 5081 patients with baseline N\u2010terminal pro B\u2010type natriuretic peptide (NT\u2010proBNP) measurement and no history of HF. The model was developed using Cox regression and validated externally in the placebo arm of the Canagliflozin Cardiovascular Assessment Study (CANVAS), which included 996 participants with T2D and established cardiovascular disease or high cardiovascular risk, and in patients treated with canagliflozin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ALTITUDE participants (mean age 64\u2009\u00b1\u20099.8\u2009years) had a median serum NT\u2010proBNP level of 157 (25th\u201375th percentile 70\u2013359) pg\/mL. Higher NT\u2010proBNP level, troponin T (TnT) level and body mass index (BMI) emerged as significant and independent predictors of new\u2010onset HF in both cohorts. The model further contained urinary albumin\u2010to\u2010creatinine ratio, glycated haemoglobin, age, haematocrit, and use of calcium channel blockers. A prediction model including these variables had a C\u2010statistic of 0.828 (95% confidence interval [CI] 0.801\u20130.855) in ALTITUDE and 0.800 (95% CI 0.720\u20130.880) in CANVAS. The C\u2010statistic of this model increased to 0.847 (95% CI 0.792\u20130.902) in patients after 1 year of canagliflozin treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with T2D, higher NT\u2010proBNP level, TnT level and BMI are independent and externally validated predictors of new\u2010onset HF, including patients using an SGLT2 inhibitor. This newly developed model may identify patients at high risk of new\u2010onset HF, contributing to early recognition and possibly prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15592","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T04:00:35Z","timestamp":1712548835000},"page":"2741-2751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prediction of new\u2010onset heart failure in patients with type 2 diabetes derived from\n                    <scp>ALTITUDE<\/scp>\n                    and\n                    <scp>CANVAS<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1218-6215","authenticated-orcid":false,"given":"Fatema","family":"Said","sequence":"first","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Arnott","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Sydney Australia"},{"name":"Department of Cardiology Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan A.","family":"Voors","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-3730","authenticated-orcid":false,"given":"Hiddo J. L.","family":"Heerspink","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health  Sydney Australia"},{"name":"Department of Clinical Pharmacy and Pharmacology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozine M.","family":"ter Maaten","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n461"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.10.172"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021498"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.069"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.7588"},{"key":"e_1_2_10_7_1","first-page":"1","article-title":"2023 focused update of the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)","volume":"44","author":"Metra M","year":"2023","journal-title":"Eur Heart 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