{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:41:34Z","timestamp":1787060494963,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M653669"],"award-info":[{"award-number":["2019M653669"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8191101420"],"award-info":[{"award-number":["8191101420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103868"],"award-info":[{"award-number":["82103868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2020JQ\u2010094"],"award-info":[{"award-number":["2020JQ\u2010094"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study investigated the depot\u2010 and sex\u2010specific associations of adiposity indicators with incident multimorbidity and comorbidity pairs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We selected 382\u2009678 adults without multimorbidity (\u22652 chronic diseases) at baseline from the UK Biobank. General obesity, abdominal obesity and body fat percentage indices were measured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cox proportional hazard regression analyses of general obesity indices revealed that for every one\u2010unit increase in body mass index, the risk of incident multimorbidity increased by 5.2% (95% confidence interval 5.0%\u20105.4%). A dose\u2010response relationship was observed between general obesity degrees and incident multimorbidity. The analysis of abdominal obesity indices showed that for every 0.1 increment in waist\u2010to\u2010height ratio and waist\u2010to\u2010hip ratio, the risk of incident multimorbidity increased by 42.0% (37.9%\u201046.2%) and 27.9% (25.7%\u201030.0%), respectively. Central obesity, as defined by waist circumference, contributed to a 23.2% increased risk of incident multimorbidity. Hip circumference and hip\u2010to\u2010height ratio had protective effects on multimorbidity onset. Consistent findings were observed for males and females. Body fat percentage elevated 3% (0.2%\u20105.9%) and 5.3% (1.1%\u20109.7%) risks of incident multimorbidity in all adults and females, respectively. Arm fat percentages elevated 5.3% (0.8%\u20109.9%) and 19.4% (11.0%\u201028.5%) risks of incident multimorbidity in all adults and males, respectively. The general obesity indices, waist circumference, waist\u2010to\u2010height ratio, waist\u2010to\u2010hip ratio and central obesity increased the onset of comorbidity pairs, whereas hip circumference and hip\u2010to\u2010height ratio decreased the onset of comorbidity pairs. These adiposity indicators mainly affect diabetes mellitus\u2010related comorbidity onset in males and hypertensive\u2010related comorbidity onset in females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Adiposity indicators are predictors of multimorbidity and comorbidity pairs and represent a promising approach for intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15610","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T04:28:25Z","timestamp":1714451305000},"page":"2890-2904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adiposity indicators exhibit depot\u2010 and sex\u2010specific associations with multimorbidity onset: A cohort study of the\n                    <scp>UK Biobank<\/scp>"],"prefix":"10.1111","volume":"26","author":[{"given":"Lu","family":"Ma","sequence":"first","affiliation":[{"name":"School of Public Health Xi'an Jiaotong University Health Science Center  Xi'an China"},{"name":"Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-5444","authenticated-orcid":false,"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaixia","family":"Li","sequence":"additional","affiliation":[{"name":"China\u2010Australia Joint Research Center for Infectious Diseases, School of Public Health Xi'an Jiaotong University Health Science Center  Xi'an 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