{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:16Z","timestamp":1787014096650,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023233","name":"National Institute for Health and Care Research Applied Research Collaboration Oxford and Thames Valley","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023233","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000557","name":"British Nutrition Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RYC2020\u2010028818\u2010I"],"award-info":[{"award-number":["RYC2020\u2010028818\u2010I"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["MCIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the association of gestational diabetes mellitus (GDM) with premature mortality and cardiovascular (CVD) outcomes and risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Parous women recruited to the UK Biobank cohort during 2006\u20102010 were followed up from their first delivery until 31 October 2021. The data were linked to Hospital Episode Statistics and mortality registries. Multivariate Cox proportional hazard models investigated associations of GDM with all\u2010cause mortality, CVD, diabetes, hypertension and dyslipidaemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The maximum total analysis time at risk and under observation was 9\u2009694\u2009090 person\u2010years. Among 220\u2009726 women, 1225 self\u2010reported or had a recorded diagnosis of GDM. After adjusting for confounders and behavioural factors, GDM was associated with increased risk for premature mortality [hazard ratio (HR): 1.44, 95% confidence interval (CI): 1.12\u20101.86], particularly CVD\u2010related death (HR: 2.38, 95% CI: 1.63\u20103.48), as well as incident total CVD (HR: 1.50, 95% CI: 1.30\u20101.74), non\u2010fatal CVD (HR: 1.41, 95% CI: 1.20\u20101.65), diabetes (HR: 14.37, 95% CI: 13.51\u201015.27), hypertension (HR: 1.49, 95% CI: 1.38\u20101.60), and dyslipidaemia (HR: 1.30, 95% CI: 1.22\u20101.39). The total CVD risk was greater in women with GDM who did not later develop diabetes than in those with GDM and diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women with GDM are at increased risk of premature death and have increased CV risk, emphasizing the importance of interventions to prevent GDM. If GDM develops, the diagnosis represents an opportunity for future surveillance and intervention to reduce CVD risk factors, prevent CVD and improve long\u2010term health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15612","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T02:59:25Z","timestamp":1714359565000},"page":"2915-2924","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Association of gestational diabetes with long\u2010term risk of premature mortality, and cardiovascular outcomes and risk factors: A retrospective cohort analysis in the\n                    <scp>UK<\/scp>\n                    Biobank"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-3307","authenticated-orcid":false,"given":"Moscho","family":"Michalopoulou","sequence":"first","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Piernas","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"},{"name":"Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Centre for Biomedical Research University of Granada  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Jebb","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gao","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9301-7458","authenticated-orcid":false,"given":"Nerys M.","family":"Astbury","sequence":"additional","affiliation":[{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford  Oxford 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