{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:54:17Z","timestamp":1782446057213,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate gastric emptying (GE) and the glycaemic response to a 75\u2010g oral glucose load in newly diagnosed, treatment\u2010na\u00efve Han Chinese with type 2 diabetes (T2D) before insulin pump therapy, after 4\u2009weeks of insulin pump therapy, and 12\u201315\u2009months after insulin pump therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Twenty participants with T2D (baseline glycated haemoglobin [\u00b1\u2009SD] 10.7%\u2009[\u00b1\u20091.2%] 93 [\u00b1\u200910] mmol\/mol) ingested a 75\u2010g glucose drink containing 150\u2009mg\n                      <jats:sup>13<\/jats:sup>\n                      C\u2010acetate, to determine the gastric half\u2010emptying time, and underwent assessment of plasma glucose and serum insulin, C\u2010peptide and glucagon\u2010like peptide\u20101 (GLP\u20101) over 180\u2009min before and after 4\u2009weeks of insulin pump therapy (discontinued for 48\u2009h before re\u2010assessment). Data were compared to those in 19 healthy participants matched for sex and age. After 12\u201315\u2009months, GE was re\u2010measured in 14 of the T2D participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, participants with T2D exhibited substantially augmented fasting and post\u2010glucose glycaemia, diminished insulin secretion, and more rapid GE (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 each), but comparable GLP\u20101, compared to healthy participants. Following insulin pump therapy, insulin secretion increased, GLP\u20101 secretion was attenuated, fasting and post\u2010glucose glycaemia were lower, and GE was slowed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 each). The slowing of GE in T2D participants was sustained over 12\u201315\u2009months of follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In newly diagnosed Han Chinese with T2D, GE is often accelerated despite poor glycaemic control and is slowed by short\u2010term insulin pump therapy. The effect on GE is maintained for at least 12\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15626","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T01:34:07Z","timestamp":1714700047000},"page":"3078-3087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gastric emptying in newly diagnosed, treatment\u2010na\u00efve Han Chinese with type 2 diabetes and the impact of 4\u2010week insulin pump therapy"],"prefix":"10.1111","volume":"26","author":[{"given":"Yixuan","family":"Sun","sequence":"first","affiliation":[{"name":"Adelaide Medical School and Centre of Research Excellence (CRE) in Translating Nutritional Science to Good Health The University of Adelaide  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nanjing First 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