{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:25Z","timestamp":1772160145057,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Gestational diabetes (GD) is a global health concern with significant implications for maternal and neonatal outcomes. This study investigates the association between early GD (eGD) diagnosis (&lt;24\u2009weeks), pharmacotherapy requirements and adverse neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A cohort of 369 pregnant women underwent a 75\u2010g oral glucose tolerance test. Maternal variables, pharmacotherapy prescriptions and neonatal outcomes were analysed employing t\u2010tests, \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests, and logistic regression. A\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Early GD increased the odds of neonatal hypoglycaemia [odds ratio (OR): 18.57,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.013] and respiratory distress syndrome (OR: 4.75,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.034). Nutritional therapy prescription by an accredited nutritionist was the most common treatment in women diagnosed after 24\u2009weeks, but those with eGD required more frequently specialized nutritional consulting\u2009+\u2009metformin to achieve glycaemic control (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.027). eGD was associated with a higher requirement of nutritional therapy prescription\u2009+\u2009metformin (OR: 2.26, 95% confidence interval: 1.25\u20104.09,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.007) and with maternal hyperglycaemia during the post\u2010partum period at 2\u2009h of the oral glucose tolerance test (OR: 1.03, 95% confidence interval: 1.02\u20101.13,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.024).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Timely diagnosis and personalized treatment of GD are desirable because an earlier presentation is related to a higher risk of adverse neonatal and maternal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15633","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T03:48:33Z","timestamp":1714708113000},"page":"3110-3118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Earlier detection of gestational diabetes impacts on medication requirements, neonatal and maternal outcomes"],"prefix":"10.1111","volume":"26","author":[{"given":"Omar Alberto","family":"Tirado\u2010Aguilar","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Instituto Nacional de Perinatolog\u00eda \u201cIsidro Espinosa de los Reyes\u201d  Mexico City 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Jafet","family":"Martinez\u2010Portilla","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Estrada\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Uribe\u2010Torres","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes  Mexico City Mexico"},{"name":"Comisi\u00f3n Interinstitucional para la Formaci\u00f3n de Recursos Humanos para la Salud  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Daniel","family":"Tirado Aguilar","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de San Luis Potosi, Faculty of Medicine  San Luis Potos\u00ed Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda","family":"Lopez\u2010Torres","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Instituto Nacional de Perinatolog\u00eda \u201cIsidro Espinosa de los Reyes\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Ramos\u2010Mendoza","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Instituto Nacional de Perinatolog\u00eda \u201cIsidro Espinosa de los Reyes\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaira Alexi","family":"Camacho\u2010Martinez","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Deparment Hospital General de Mexico \u201cDr. Eduardo Liceaga\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson Yesid","family":"Aguilar\u2010Jaimes","sequence":"additional","affiliation":[{"name":"Maternal Fetal Medicine Unit, Clinica Chicamocha SA  Bucaramanga Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9524-4133","authenticated-orcid":false,"given":"Johnatan","family":"Torres\u2010Torres","sequence":"additional","affiliation":[{"name":"Clinical Research Branch, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes  Mexico City Mexico"},{"name":"Gynecology and Obstetrics Deparment Hospital General de Mexico \u201cDr. Eduardo Liceaga\u201d  Mexico City 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