{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:25Z","timestamp":1772160145492,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>In this study, we investigated glucose and lactate kinetics during a 75\u2009g oral glucose tolerance test (OGTT) in 23 overweight and obese adolescents and assessed putative differences among participants with and without metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We enrolled 23 young people (six girls) with obesity [body mass index 33 (29\u201037)]. Glucose\u2010lactate kinetics parameters (disposal glucose insulin sensitivity, SI\n                      <jats:sub>D<\/jats:sub>\n                      ; fraction of glucose converted into lactate, fr; fractional lactate clearance rate, k\n                      <jats:sub>L<\/jats:sub>\n                      ) and lactate production rate (LPR) were estimated using the oral glucose\u2010lactate minimal model. MASLD presence was assessed using the proton density fat fraction. We analysed glucose, lactate and LPR time to peak, peak values and area under the curve and evaluated differences using the Wilcoxon test. MASLD and no\u2010MASLD participants were compared using the Mann\u2010Whitney test. Correlations between parameters were assessed using the Spearman correlation coefficient (\u03c1). We also tested the performance of two (4 or 3\u2009h OGTT) protocols in estimating oral glucose\u2010lactate minimal model and LPR parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Glucose peaks 30\u2009min earlier than lactate (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.0019). This pattern was present in the no\u2010MASLD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). LPR peaks 30\u2009min later in the MASLD group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.02). LPR and k\n                      <jats:sub>L<\/jats:sub>\n                      were higher in MASLD, suggesting higher glycolysis and lactate utilization. SI\n                      <jats:sub>D<\/jats:sub>\n                      and fr correlate significantly (\u03c1\u2009=\u2009\u22120.55,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.008). SI\n                      <jats:sub>D<\/jats:sub>\n                      and fr were also correlated with the body mass index, (\u03c1\u2009=\u2009\u22120.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.04; and \u03c1\u2009=\u20090.45;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.03). The protocol duration did not influence the estimates of the parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Youth with MASLD showed a delayed glucose metabolism, possibly because of greater utilization of the underlying substrates. A 3\u2010h OGTT may be used to assess lactate metabolism effectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15648","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T06:05:44Z","timestamp":1715666744000},"page":"3207-3212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modelling and assessment of\n                    <scp>glucose\u2010lactate<\/scp>\n                    kinetics in youth with\u00a0overweight, obesity\u00a0and metabolic dysfunction\u2010associated steatotic liver disease: A pilot study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4097-7943","authenticated-orcid":false,"given":"Jacopo","family":"Bonet","sequence":"first","affiliation":[{"name":"Department of Information Engineering  Padua Italy"},{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delaney","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafaela","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loretta","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kansas University Medical Center  Kansas City Kansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Center for Children's Healthy Lifestyles &amp; Nutrition  Kansas City Kansas USA"},{"name":"University of Missouri\u2010Kansas City School of Medicine  Kansas City Kansas USA"},{"name":"Division of Weight Management, Children's Mercy  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Universita degli Studi di Napoli Federico II Scuola di Medicina e Chirurgia  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Dalla Man","sequence":"additional","affiliation":[{"name":"Department of Information Engineering  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6437-4173","authenticated-orcid":false,"given":"Nicola","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Department of Medicine and Health Sciences \u201cV. Tiberio\u201d University of Molise  Campobasso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010020\u20100183\u2010z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10\u20100284"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2021.3124143"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523621"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.2.412"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20101587"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.184"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1062341"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0022\u20103476(03)00325\u20101"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30035"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u2010012160240\u20106.50009\u20100"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00358.2014"},{"key":"e_1_2_9_14_1","volume-title":"MATLAB Version R2022b","author":"MATLAB","year":"2022"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.9.4228"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:42:54Z","timestamp":1761882174000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,14]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/dom.15648"],"URL":"https:\/\/doi.org\/10.1111\/dom.15648","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15648\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15648\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15648\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15648\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15648\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15648\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,14]]},"assertion":[{"value":"2024-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}