{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:26:49Z","timestamp":1788316009073,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019619","name":"International Diabetes Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012812","name":"Higher College of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Experimental hypoglycaemia blunts the counterregulatory hormone and symptom responses to a subsequent episode of hypoglycaemia. In this study, we aimed to assess the associations between antecedent exposure and continuous glucose monitoring (CGM)\u2010recorded hypoglycaemia during a 1\u2010week period and the counterregulatory responses to subsequent experimental hypoglycaemia in people with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Forty\u2010two people with type 1 diabetes (20 females, mean\u2009\u00b1\u2009SD glycated haemoglobin 7.8%\u2009\u00b1\u20091.0%, diabetes duration median (interquartile range) 22.0 (10.5\u201034.9) years, 29 CGM users, and 19 with impaired awareness of hypoglycaemia) wore an open intermittently scanned CGM for 1 week to detect hypoglycaemic exposure before a standardized hyperinsulinaemic\u2010hypoglycaemic [2.8\u2009\u00b1\u20090.1\u2009mmol\/L (50.2\u2009\u00b1\u20092.3\u2009mg\/dl)] glucose clamp. Symptom responses and counterregulatory hormones were measured during the clamp. The study is part of the HypoRESOLVE project.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CGM\u2010recorded hypoglycaemia in the week before the clamp was negatively associated with adrenaline response [\u03b2 \u22120.09, 95% CI (\u22120.16, \u22120.02) nmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.014], after adjusting for CGM use, awareness of hypoglycaemia, glycated haemoglobin and total daily insulin dose. This was driven by level 2 hypoglycaemia [&lt;3.0\u2009mmol\/L (54\u2009mg\/dl)] [\u03b2 \u22120.21, 95% CI (\u22120.41, \u22120.01) nmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.034]. CGM\u2010recorded hypoglycaemia was negatively associated with total, autonomic, and neuroglycopenic symptom responses, but these associations were lost after adjusting for potential confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Recent exposure to CGM\u2010detected hypoglycaemia was independently associated with an attenuated adrenaline response to experimental hypoglycaemia in people with type 1 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15649","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T03:43:55Z","timestamp":1716349435000},"page":"3213-3222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between recent exposure to continuous glucose monitoring\u2010recorded hypoglycaemia and counterregulatory and symptom responses to subsequent controlled hypoglycaemia in people with type 1 diabetes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2560-9915","authenticated-orcid":false,"given":"Cecilie H.","family":"Svensson","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Nephrology Nordsj\u00e6llands Hospital  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6344-5408","authenticated-orcid":false,"given":"Therese W.","family":"Fabricius","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nephrology Nordsj\u00e6llands Hospital  Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-7669","authenticated-orcid":false,"given":"Clementine E. M.","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5431-824X","authenticated-orcid":false,"given":"Peter L.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nephrology Nordsj\u00e6llands Hospital  Hiller\u00f8d Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0322-1653","authenticated-orcid":false,"given":"Cees J.","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2425-9565","authenticated-orcid":false,"given":"Simon R.","family":"Heller","sequence":"additional","affiliation":[{"name":"Department of Oncology and Metabolism University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2686-5531","authenticated-orcid":false,"given":"Stephanie A.","family":"Amiel","sequence":"additional","affiliation":[{"name":"Department of Diabetes, School of Cardiovascular and Metabolic Medicine and Science Faculty of Life Sciences &amp; Medicine, King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3957-1981","authenticated-orcid":false,"given":"Rory J.","family":"McCrimmon","sequence":"additional","affiliation":[{"name":"School of Medicine University of Dundee  Dundee 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