{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:42:25Z","timestamp":1772160145585,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008966","name":"Soci\u00e9t\u00e9 Francophone du Diab\u00e8te","doi-asserted-by":"publisher","award":["SFD\u2010Bourse de recherche 2017"],"award-info":[{"award-number":["SFD\u2010Bourse de recherche 2017"]}],"id":[{"id":"10.13039\/501100008966","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The use of vitamin K antagonists (VKAs) may increase the risk of peripheral arterial disease (PAD) because vitamin K is a strong inhibitor of medial arterial calcification. Type 2 diabetes (T2D) exposes patients to an increased risk of PAD. We examined how the use of VKAs modulates the risk of incident PAD in people with T2D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>SURDIAGENE is a French cohort including 1468 patients with T2D with a prospective follow\u2010up from 2002 to 2015. The primary outcome of the current analysis was the first occurrence of PAD, a composite of lower\u2010limb amputation (LLA) or lower\u2010limb revascularization. LLA and lower\u2010limb revascularization were considered individually as secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a 7\u2010year median follow\u2010up, PAD occurred in 147 (10%) of the 1468 participants. The use of VKAs was not significantly associated with the risk of PAD [multivariable adjusted hazard ratio (HR) 1.42, 95% confidence interval (CI), 0.88\u20102.31]. During the study period, LLA and lower\u2010limb revascularization occurred in 82 (6%) and 105 (7%) participants, respectively. The use of VKAs was significantly associated with increased risk of LLA [multivariable adjusted HR 1.90 (95% CI, 1.04\u20103.47)], but not lower\u2010limb revascularization [multivariable adjusted HR 1.08 (95% CI, 0.59\u20101.97)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this prospective study, we did not observe any excess risk of PAD requiring lower\u2010limb revascularization in people with type 2 diabetes using VKAs. However, our data suggest a high risk of LLA in VKA users. Further studies are required to confirm this observation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15656","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T05:25:26Z","timestamp":1715750726000},"page":"3290-3298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A prospective observational study to evaluate a possible relationship between vitamin K antagonist therapy and risk of peripheral arterial disease in patients with type 2 diabetes"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7348-7161","authenticated-orcid":false,"given":"Olivier","family":"Bourron","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9 M\u00e9decine, Assistance Publique H\u00f4pitaux de Paris (APHP), Diabetology Department, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, INSERM UMRS_1138, Centre de Recherche des Cordeliers, Institute of Cardiometabolism and Nutrition (ICAN)  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel","family":"Mohammedi","sequence":"additional","affiliation":[{"name":"H\u00f4pital Haut\u2010L\u00e9v\u00eaque, Department of Endocrinology, Diabetes and Nutrition, University of Bordeaux, Faculty of Medicine, INSERM unit 1034 Biology of Cardiovascular Diseases, Bordeaux University Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"De Keizer","sequence":"additional","affiliation":[{"name":"Centre d'Investigation Clinique CIC1402 Universit\u00e9 de Poitiers, CHU de Poitiers, INSERM  Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Schneider","sequence":"additional","affiliation":[{"name":"Centre d'Investigation Clinique CIC1402 Universit\u00e9 de Poitiers, CHU de Poitiers, INSERM  Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-6994","authenticated-orcid":false,"given":"Samy","family":"Hadjadj","sequence":"additional","affiliation":[{"name":"L'institut du Thorax, INSERM, CNRS, UNIV Nantes, Diabetology Department, CHU Nantes  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Jean","family":"Saulnier","sequence":"additional","affiliation":[{"name":"Centre d'Investigation Clinique CIC1402 Universit\u00e9 de Poitiers, CHU de Poitiers, INSERM  Poitiers 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