{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:54:36Z","timestamp":1793141676019,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070588"],"award-info":[{"award-number":["82070588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370577"],"award-info":[{"award-number":["82370577"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR203319"],"award-info":[{"award-number":["NIHR203319"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyse the association between serum bile acid (BA) profile and heart failure (HF) with preserved ejection fraction (HFpEF) in patients with metabolic dysfunction\u2010associated fatty liver disease (MAFLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 163 individuals with biopsy\u2010proven MAFLD undergoing transthoracic echocardiography for any indication. HFpEF was defined as left ventricular ejection fraction &gt;50% with at least one echocardiographic feature of HF (left ventricular diastolic dysfunction, abnormal left atrial size) and at least one HF sign or symptom. Serum levels of 38 BAs were analysed using ultra\u2010performance liquid chromatography coupled with tandem mass spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 163 patients enrolled (mean age 47.0\u2009\u00b1\u200912.8\u2009years, 39.3% female), 52 (31.9%) and 43 (26.4%) met the HFpEF and pre\u2010HFpEF criteria, and 38 serum BAs were detected. Serum ursodeoxycholic acid (UDCA) and hyocholic acid (HCA) species were lower in patients with HFpEF and achieved statistical significance after correction for multiple comparisons. Furthermore, decreases in glycoursodeoxycholic acid and tauroursodeoxycholic acid were associated with HF status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this exploratory study, specific UDCA and HCA species were associated with HFpEF status in adults with biopsy\u2010confirmed MAFLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15709","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:14:11Z","timestamp":1718349251000},"page":"3684-3695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Serum bile acid profiles are associated with heart failure with preserved ejection fraction in patients with metabolic dysfunction\u2010associated fatty liver disease: An exploratory study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0818","authenticated-orcid":false,"given":"Xiao\u2010Dong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The Heart Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui\u2010Fang","family":"Xu","sequence":"additional","affiliation":[{"name":"The Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Child Health  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-5004","authenticated-orcid":false,"given":"Qin\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Care Center The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"},{"name":"Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Center for Prevention of Cardiovascular Disease, Section on Cardiovascular Medicine Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital  Liverpool UK"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Li","family":"Chen","sequence":"additional","affiliation":[{"name":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-3900","authenticated-orcid":false,"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Verona  Verona Italy"},{"name":"Metabolic Diseases Research Unit IRCCS Sacro Cuore \u2013 Don Calabria Hospital  Negrar di Valpolicella Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-7753","authenticated-orcid":false,"given":"Christopher D.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southampton, University of Southampton, Southampton General Hospital  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3543-8036","authenticated-orcid":false,"given":"Na","family":"Tian","sequence":"additional","affiliation":[{"name":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5630-8759","authenticated-orcid":false,"given":"Tie","family":"Xiao","sequence":"additional","affiliation":[{"name":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5427-5401","authenticated-orcid":false,"given":"Chen\u2010Xiao","family":"Huang","sequence":"additional","affiliation":[{"name":"MAFLD Research Center, Department of Hepatology The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-7266","authenticated-orcid":false,"given":"Yan","family":"Ni","sequence":"additional","affiliation":[{"name":"The Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Child Health  Hangzhou 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