{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:08:26Z","timestamp":1791457706920,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"S6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diabetic nephropathy, also known as diabetic kidney disease (DKD), remains a challenge in clinical practice as this is the major cause of kidney failure worldwide. Clinical trials do not answer all the questions raised in clinical practice and real\u2010world evidence provides complementary insights from randomized controlled trials. Real\u2010life longitudinal data highlight the need for improved screening and management of diabetic nephropathy in primary care. Adherence to the recommended guidelines for comprehensive care appears to be suboptimal in clinical practice in patients with DKD. Barriers to the initiation of sodium\u2010glucose cotransporter\u20102 (SGLT2) inhibitors for patients with DKD persist in clinical practice, in particular for the elderly. Attainment of blood pressure targets often remains an issue. Initiation of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) in routine clinical practice is associated with a reduced risk of albuminuria progression and a possible beneficial effect on kidney function. Real\u2010world evidence confirms a beneficial effect of SGLT2 inhibitors on the decline of glomerular filtration, even in the absence of albuminuria, with a lower risk of acute kidney injury events compared to GLP\u20101RA use. In addition, SGLT2 inhibitors confer a lower risk of hyperkalaemia after initiation compared with dipeptidyl peptidase\u20104 inhibitors in patients with DKD. Data from a large population indicate that diuretic treatment increases the risk of a significant decline in glomerular filtration rate in the first few weeks of treatment after SGLT2 inhibitor initiation. The perspective for a global approach targeting multifaceted criteria for diabetic individuals with DKD is emerging based on real\u2010world evidence but there is still a long way to go to achieve this goal.<\/jats:p>","DOI":"10.1111\/dom.15710","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T04:34:09Z","timestamp":1718858049000},"page":"55-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A review of the latest real\u2010world evidence studies in diabetic kidney disease: What have we learned about clinical practice and the clinical effectiveness of interventions?"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9255-8228","authenticated-orcid":false,"given":"Fabrice","family":"Bonnet","sequence":"first","affiliation":[{"name":"Department of Diabetology, CHU de Rennes, Universit\u00e9 de Rennes 1  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Diabetes, School of Translational Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Koppe","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, INSERM, INRAE Claude Bernard Lyon 1 University  Pierre B\u00e9nite France"},{"name":"Department of Nephrology and Nutrition, Hospices Civils de Lyon Centre Hospitalier Lyon\u2010Sud  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Fouque","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, INSERM, INRAE Claude Bernard Lyon 1 University  Pierre B\u00e9nite France"},{"name":"Department of Nephrology and Nutrition, Hospices Civils de Lyon Centre Hospitalier Lyon\u2010Sud  Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Candido","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical and Health Sciences University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14601"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2022.06.013"},{"key":"e_1_2_20_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019010064"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2025845"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30384-5"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.121.007875"},{"issue":"4","key":"e_1_2_20_8_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2020.06.019","article-title":"KDIGO 2020 clinical practice guideline for diabetes Management in Chronic Kidney Disease","volume":"98","author":"Kidney Disease: Improving Global Outcomes Diabetes Work G","year":"2020","journal-title":"Kidney Int"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)07368-1"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1908"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706245"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01343-1"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.11.039"},{"key":"e_1_2_20_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15507"},{"key":"e_1_2_20_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024816"},{"key":"e_1_2_20_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-021-02394-y"},{"key":"e_1_2_20_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2020.05.005"},{"key":"e_1_2_20_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15194"},{"key":"e_1_2_20_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwac315"},{"key":"e_1_2_20_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-021-02381-3"},{"key":"e_1_2_20_21_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008070667"},{"key":"e_1_2_20_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.04.032"},{"key":"e_1_2_20_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001286"},{"key":"e_1_2_20_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-43614-9"},{"key":"e_1_2_20_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad404"},{"key":"e_1_2_20_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12160"},{"issue":"5","key":"e_1_2_20_27_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2022.06.008","article-title":"KDIGO 2022 clinical practice guideline for diabetes Management in Chronic Kidney Disease","volume":"102","author":"Kidney Disease: Improving Global Outcomes Diabetes Work G","year":"2022","journal-title":"Kidney Int"},{"key":"e_1_2_20_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2023.101498"},{"key":"e_1_2_20_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2012.08.004"},{"key":"e_1_2_20_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01777-9"},{"key":"e_1_2_20_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.11.011"},{"key":"e_1_2_20_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01963-9"},{"key":"e_1_2_20_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02150-0"},{"key":"e_1_2_20_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70194-9"},{"key":"e_1_2_20_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.02.030"},{"key":"e_1_2_20_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14976"},{"key":"e_1_2_20_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.18360"},{"key":"e_1_2_20_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1603827"},{"key":"e_1_2_20_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607141"},{"key":"e_1_2_20_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31150-X"},{"key":"e_1_2_20_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15185"},{"key":"e_1_2_20_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01829-0"},{"key":"e_1_2_20_43_1","doi-asserted-by":"publisher","DOI":"10.14740\/cr1441"},{"key":"e_1_2_20_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01258-x"},{"key":"e_1_2_20_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01572-y"},{"key":"e_1_2_20_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15111"},{"key":"e_1_2_20_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13965"},{"key":"e_1_2_20_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14799"},{"key":"e_1_2_20_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14239"},{"key":"e_1_2_20_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01396-2"},{"key":"e_1_2_20_51_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1890"},{"key":"e_1_2_20_52_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-1081"},{"key":"e_1_2_20_53_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3761"},{"key":"e_1_2_20_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164118802759"},{"key":"e_1_2_20_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13508"},{"key":"e_1_2_20_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2022.110200"},{"key":"e_1_2_20_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2022.101418"},{"key":"e_1_2_20_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-024-06126-3"},{"key":"e_1_2_20_59_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1464"},{"key":"e_1_2_20_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2021.101315"},{"key":"e_1_2_20_61_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-2186"},{"key":"e_1_2_20_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.10.046"},{"key":"e_1_2_20_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-022-05694-6"},{"key":"e_1_2_20_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02773-x"},{"key":"e_1_2_20_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023.11.025"},{"key":"e_1_2_20_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfad026"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T01:58:04Z","timestamp":1761875884000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":65,"journal-issue":{"issue":"S6","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/dom.15710"],"URL":"https:\/\/doi.org\/10.1111\/dom.15710","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15710\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v1\/review5","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v1\/review6","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15710\/v2\/review3","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,20]]},"assertion":[{"value":"2024-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}