{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:42:11Z","timestamp":1790127731233,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the effect of dipeptidyl peptidase\u20104 inhibitors (DPP4\u2010Is) and glucagon\u2010like peptide\u20101 receptor agonists (GLP1\u2010RAs) on diabetic foot ulcer (DFU) and DFU\u2010related outcomes (lower limb amputation [LLA], DFU\u2010related hospitalization and mortality).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a cohort study with data from the Clinical Practice Research Datalink Aurum database with linkage to hospital data. We included people with type 2 diabetes starting treatment with metformin. Then we propensity score matched new users of DPP4\u2010Is and sulphonylureas (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200998\u2009770), and new users of GLP1\u2010RAs and insulin (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200925\u2009422). Cox proportional hazards models estimated the hazard ratios (HRs) for the outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed a lower risk of DFU with both DPP4\u2010I use versus sulphonylurea use (HR 0.88, 95% confidence interval [CI]: 0.79\u20100.97) and GLP1\u2010RA use versus insulin use (HR 0.44, 95% CI: 0.32\u20100.60) for short\u2010term exposure (\u2264\u2009400\u2009days) and HR 0.74 (95% CI: 0.60\u20100.92) for long\u2010term exposure (&gt;400\u2009days). Furthermore, the risks of hospitalization and mortality were lower with both DPP4\u2010I use and GLP1\u2010RA use. The risk of LLA was lower with GLP1\u2010RA use. The results remained consistent across several sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Incretin\u2010based therapy was associated with a lower risk of DFU and DFU\u2010related outcomes. This suggests benefits for the use of this treatment in people at risk of DFU.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15721","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:19:12Z","timestamp":1719879552000},"page":"3764-3780","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Incretin\u2010based therapy and the risk of diabetic foot ulcers and related events"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3878-8302","authenticated-orcid":false,"given":"Nikki C. C.","family":"Werkman","sequence":"first","affiliation":[{"name":"Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht Institute of Pharmaceutical Sciences  Utrecht The Netherlands"},{"name":"Department of Clinical Pharmacy &amp; Toxicology Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna H. M.","family":"Driessen","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht Institute of Pharmaceutical Sciences  Utrecht The Netherlands"},{"name":"Department of Clinical Pharmacy &amp; Toxicology Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf H.","family":"Klungel","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht Institute of Pharmaceutical Sciences  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas S.","family":"Schaper","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht The Netherlands"},{"name":"Department of Internal Medicine, Division of Endocrinology Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick C.","family":"Souverein","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht Institute of Pharmaceutical Sciences  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8752-3223","authenticated-orcid":false,"given":"Coen D. A.","family":"Stehouwer","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht The Netherlands"},{"name":"Department of Internal Medicine Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3633-2504","authenticated-orcid":false,"given":"Johannes T. H.","family":"Nielen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy &amp; Toxicology Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-020-00383-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0043"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0940-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2021.30.Sup6.S34"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12683"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.04.008"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.10.025"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.096479"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2013.04.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.09.024"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1145-4"},{"key":"e_1_2_8_14_1","unstructured":"CPRD Aurum Source file May 2022 (Version 2022.05.001). In: Datalink CPR editor: Clinical Practice Research Datalink.2022."},{"key":"e_1_2_8_15_1","unstructured":"CPRD Aurum HES APC January 2022 (Version 2022.01.001). In: Datalink CPR editor: Clinical Practice Research Datalink.2022."},{"key":"e_1_2_8_16_1","unstructured":"CPRD Aurum Small Area data (patient) January 2022 (Version 2022.01.001). In: Datalink CPR editor: Clinical Practice Research Datalink.2022."},{"key":"e_1_2_8_17_1","unstructured":"NICE.Type 2 diabetes in adults: management.2022[updated 29 June 2022]. Available from:https:\/\/www.nice.org.uk\/guidance\/ng28"},{"key":"e_1_2_8_18_1","unstructured":"Methodology WCCfDS.ATC\/DDD Index 2023 2023. [updated 23 January 2023]. 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