{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:15:17Z","timestamp":1793499317756,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the efficacy and safety of a fixed\u2010ratio combination of insulin glargine 100\u2009U\/mL plus lixisenatide (iGlarLixi) with premixed insulin, insulin degludec plus insulin aspart (IDegAsp), in Chinese people with type 2 diabetes (T2D) suboptimally controlled with oral antidiabetic drug(s) (OADs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In Soli\u2010D, a 24\u2010week, multicentre, open\u2010label, study, insulin\u2010na\u00efve adults were randomized 1:1 to once\u2010daily injections of iGlarLixi (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009291) or IDegAsp (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009291), with continued metformin\u2009\u00b1\u2009sodium\u2010glucose co\u2010transporter\u20102 inhibitors. The primary endpoint was non\u2010inferiority in HbA1c change from baseline to week 24. Key secondary endpoints included superiority in HbA1c change and body weight (BW) change at week 24. Hypoglycaemia rates were also assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At week 24, iGlarLixi showed non\u2010inferiority and superiority over IDegAsp in HbA1c reduction (least squares [LS] mean difference: \u22120.20 [95% confidence interval {CI}: \u20130.33, \u22120.07];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001 for non\u2010inferiority; [97.5% CI: \u20130.35, \u22120.05];\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.003 for superiority). iGlarLixi decreased BW and IDegAsp increased BW from baseline to week 24, with a statistically significant LS mean difference of \u22121.49\u2009kg in favour of iGlarLixi (97.5% CI: \u20132.32, \u22120.66;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Event rates (per person\u2010year) for American Diabetes Association (ADA) Level 1, 2 or 3 hypoglycaemia were lower for iGlarLixi (1.90) versus IDegAsp (2.72) (relative risk: 0.71; 95% CI: 0.52, 0.98). No ADA Level 3 hypoglycaemia or unexpected safety findings were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Chinese people with T2D suboptimally controlled with OADs, once\u2010daily iGlarLixi provided better glycaemic control with BW benefit and lower hypoglycaemia event rates versus IDegAsp.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15724","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T14:30:26Z","timestamp":1719066626000},"page":"3791-3800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The efficacy and safety of\n                    <scp>iGlarLixi<\/scp>\n                    versus\n                    <scp>IDegAsp<\/scp>\n                    in\n                    <scp>Chinese<\/scp>\n                    people with type 2 diabetes suboptimally controlled with oral antidiabetic drugs: The\n                    <scp>Soli\u2010D<\/scp>\n                    randomized controlled trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-4072","authenticated-orcid":false,"given":"Ming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Tianjin Medical University General Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Medical Centre, Chinese People's Liberation Army General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7795-6498","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7242-760X","authenticated-orcid":false,"given":"Yanbing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianling","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Dalian Medical University  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Sanofi  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Lauand","sequence":"additional","affiliation":[{"name":"Sanofi  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Souhami","sequence":"additional","affiliation":[{"name":"Sanofi  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiewen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sanofi  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiya","family":"Xu","sequence":"additional","affiliation":[{"name":"Sanofi  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Du","sequence":"additional","affiliation":[{"name":"Sanofi  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3344-3540","authenticated-orcid":false,"given":"Yiming","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Medical Centre, Chinese People's Liberation Army General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"SoliD trial investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"IDF Diabetes Atlas [Internet]","author":"Magliano DJ","year":"2021"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"S158","article-title":"9. 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