{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:56:17Z","timestamp":1789660577865,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate how a change in body position with light\u2010intensity physical activity (PA) \u2018snacks\u2019 (LIPAS, alternate sitting and standing, walking or standing continuously) compared with uninterrupted prolonged sitting affects glucose metabolism and heart rate variability (HRV) parameters in young adults with overweight and obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We conducted a four\u2010arm randomized controlled crossover trial. The following conditions were tested during an 8\u2010h simulated workday: uninterrupted prolonged sitting (SIT), alternate sitting and standing (SIT\u2010STAND; 2.5\u2009h total), continuous standing (STAND), and continuous walking (1.0 mph; WALK). The primary outcome was to investigate how a change in body position (alternate sitting and standing, walking or standing continuously) compared with uninterrupted sitting affects mean 8\u2010h glucose metabolism. Secondary outcomes included the effects on 2\u2010h postprandial glucose concentrations, as well as on 8\u2010h\/24\u2010h heart rate and HRV parameters, in the respective study arms. Capillary blood samples were drawn from an hyperemised earlobe in the fasted state and once every hour during each trial intervention by puncturing the earlobe with a lancet and collecting 20\u2009\u03bcL of blood (Biosen S\u2010Line Lab+; EKF diagnostics, Barleben, Germany). HRV was assessed for 24 h including the 8\u2010h intervention phase, and a home phase by means of a Holter electrocardiogram. All participants received the same standardized non\u2010relativised breakfast and lunch during the four trial visits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventeen individuals (eight women, mean age 23.4\u2009\u00b1\u20093.3\u2009years, body mass index 29.7\u2009\u00b1\u20093.8\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , glycated haemoglobin level 34.8\u2009\u00b1\u20093.1\u2009mmol\/mol [5.4\u2009\u00b1\u20090.3%], body fat 31.8\u2009\u00b1\u20098.2%) completed all four trial arms. Compared with SIT (89.4\u2009\u00b1\u20096.8\u2009mg\/dL), 8\u2010h mean glucose was lower in all other conditions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and this was statistically significant compared with WALK (86.3\u2009\u00b1\u20095.2\u2009mg\/dL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034). Two\u2010hour postprandial glucose after breakfast was approximately 7% lower for WALK compared with SIT (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Furthermore, significant time\u2009\u00d7\u2009condition effects on HRV parameters favouring light\u2010intensity walking were observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Replacement and interruption of prolonged sitting with light\u2010intensity walking showed a significant blood glucose\u2010lowering effect and improved HRV during an 8\u2010h work environment in young adults with overweight and obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15732","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:39:10Z","timestamp":1719362350000},"page":"3849-3859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of light\u2010intensity physical activity on cardiometabolic parameters in young adults with overweight and obesity: The\n                    <scp>SED<\/scp>\n                    \u2010\n                    <scp>ACT<\/scp>\n                    randomized controlled crossover trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1458-2355","authenticated-orcid":false,"given":"Sascha W.","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Division of Theory and Practice of Sports and Fields of Physical Activity, BaySpo\u2010Bayreuth Center of Sport Science University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis","family":"Schierbauer","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2010Bayreuth Center of Sport Science University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2010Bayreuth Center of Sport Science University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Voit","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2010Bayreuth Center of Sport Science University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auguste","family":"Grothoff","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2010Bayreuth Center of Sport Science University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Wachsmuth","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2010Bayreuth Center of Sport Science University of Bayreuth  Bayreuth Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"R\u00f6ssler","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut K.","family":"Lackner","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-0685","authenticated-orcid":false,"given":"Othmar","family":"Moser","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2010Bayreuth Center of Sport Science University of Bayreuth  Bayreuth Germany"},{"name":"Interdisciplinary Metabolic Medicine Trials Unit, Department of Internal Medicine, Division of Endocrinology and Diabetology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12966-017-0525-8"},{"key":"e_1_2_9_3_1","first-page":"1","article-title":"Combined relationship of physical inactivity and sedentary behavior with the prevalence of noncommunicable chronic diseases: data from 52,675 Brazilian adults and elderly","volume":"22","author":"Bertuol C","year":"2021","journal-title":"Eur J Sport Sci"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.02.031"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2020.04.005"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"19","article-title":"Too much sitting and metabolic risk\u2014has modern technology caught up with us?","volume":"6","author":"Dunstan 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