{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:44:54Z","timestamp":1787867094554,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515010177"],"award-info":[{"award-number":["2023A1515010177"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The association of overweight\/obesity and metabolic dysfunction\u2010associated steatotic liver disease (MASLD) in young adulthood with subclinical atherosclerosis [coronary artery calcification (CAC) and abdominal aortic calcification (AAC)] by middle age is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In total, 2274 participants aged 28\u201039\u2009years from the coronary artery risk development in young adults study at year 10 (1995\u20101996) who were re\u2010examined 15\u2009years later were included. CAC and AAC were measured at year 25 using computed tomography. We examined the utility of three young adult phenotypes (lean group; overweight\/obese group; overweight\/obese MASLD group) at year 10 in predicting CAC or AAC by middle age. Modified Poisson regression was used to estimate the association between groups and CAC, and AAC. Independent determinates of CAC and AAC were determined with linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with individuals categorized as lean in young adulthood, the relative risk for CAC by middle age was 1.09 (95% confidence interval: 0.93\u20101.28) for those with overweight\/obesity and 1.32 (95% confidence interval: 1.08\u20101.61) for those with overweight\/obesity\u2010related MASLD. For AAC, no difference was observed between these three groups. Group, systolic blood pressure and group\u2009\u00d7\u2009systolic blood pressure interaction were all the independent determinates for CAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, young adults with overweight\/obesity\u2010related MASLD have a higher risk of developing CAC by middle age. These abnormalities are only partially explained by traditional cardiovascular risk factors, and overweight\/obesity\u2010related MASLD has an independent impact on CAC. Our study provides evidence for identifying young adults at higher risk of developing subclinical atherosclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15733","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T05:19:37Z","timestamp":1719465577000},"page":"3860-3867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association of overweight\/obesity and overweight\/obesity\u2010related metabolic dysfunction\u2010associated steatotic liver disease in young adults with coronary artery calcification later in life"],"prefix":"10.1111","volume":"26","author":[{"given":"Jia\u2010Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou 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