{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:40:57Z","timestamp":1792172457950,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["17\/0005659"],"award-info":[{"award-number":["17\/0005659"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020013","name":"NIHR Leicester Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020624","name":"NIHR Nottingham Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine the impact of impaired glycaemic regulation (IGR) and exercise training on hepatic lipid composition in men with metabolic dysfunction\u2010associated steatotic liver disease (MASLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In Part A (cross\u2010sectional design), 40 men with MASLD (liver proton density fat fraction [PDFF]\u2009\u22655.56%) were recruited to one of two groups: (1) normal glycaemic regulation (NGR) group (glycated haemoglobin [HbA1c]\u2009&lt;\u200942\u2009mmol\u2219mol\n                      <jats:sup>\u22121<\/jats:sup>\n                      [&lt;6.0%];\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) or (2) IGR group (HbA1c\u2009\u2265\u200942\u2009mmol\u2219mol\n                      <jats:sup>\u22121<\/jats:sup>\n                      [\u22656.0%];\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926). In Part B (randomized controlled trial design), participants in the IGR group were randomized to one of two 6\u2010week interventions: (1) exercise training (EX; 70%\u201375% maximum heart rate; four sessions\/week;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913) or (2) non\u2010exercise control (CON;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913). Saturated (SI; primary outcome), unsaturated (UI) and polyunsaturated (PUI) hepatic lipid indices were determined using proton magnetic resonance spectroscopy. Additional secondary outcomes included liver PDFF, HbA1c, fasting plasma glucose (FPG), homeostatic model assessment of insulin resistance (HOMA\u2010IR), peak oxygen uptake (VO\n                      <jats:sub>2<\/jats:sub>\n                      peak), and plasma cytokeratin\u201018 (CK18) M65, among others.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In Part A, hepatic SI was higher and hepatic UI was lower in the IGR versus the NGR group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), and this hepatic lipid profile was associated with higher HbA1c levels, FPG levels, HOMA\u2010IR and plasma CK18 M65 levels (\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>s<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009\u22650.320). In Part B, hepatic lipid composition and liver PDFF were unchanged after EX versus CON (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2265\u20090.257), while FPG was reduced and VO\n                      <jats:sub>2<\/jats:sub>\n                      peak was increased (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.030). \u0394VO\n                      <jats:sub>2<\/jats:sub>\n                      peak was inversely associated with \u0394hepatic SI (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.433) and positively associated with \u0394hepatic UI and \u0394hepatic PUI (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009\u2265\u20090.433).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Impaired glycaemic regulation in MASLD is characterized by greater hepatic lipid saturation; however, this composition is not altered by 6\u2009weeks of moderate\u2010intensity exercise training.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15755","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:25:02Z","timestamp":1720484702000},"page":"4030-4042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction\u2010associated steatotic liver disease but is not altered by 6\u2009weeks of exercise training"],"prefix":"10.1111","volume":"26","author":[{"given":"Scott A.","family":"Willis","sequence":"first","affiliation":[{"name":"National Centre for Sport and Exercise Medicine School of Sport, Exercise and Health Sciences, Loughborough University  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Hospitals NHS Trust and the University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron P.","family":"Sherry","sequence":"additional","affiliation":[{"name":"National Centre for Sport and Exercise Medicine School of Sport, Exercise and Health Sciences, Loughborough University  Loughborough UK"},{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust and the University of Leicester  Leicester UK"},{"name":"Lifespan and Population Health, School of Medicine University of Nottingham  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0395-7329","authenticated-orcid":false,"given":"Jack A.","family":"Sargeant","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust and the University of Leicester  Leicester UK"},{"name":"Leicester Diabetes Centre University Hospitals 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J.","family":"Stensel","sequence":"additional","affiliation":[{"name":"National Centre for Sport and Exercise Medicine School of Sport, Exercise and Health Sciences, Loughborough University  Loughborough UK"},{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust and the University of Leicester  Leicester UK"},{"name":"Faculty of Sport Sciences Waseda University  Tokorozawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3932-3339","authenticated-orcid":false,"given":"David R.","family":"Webb","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre University Hospitals of Leicester NHS Trust and the University of Leicester  Leicester UK"},{"name":"Diabetes Research Centre University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-9371","authenticated-orcid":false,"given":"Melanie 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