{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:10:24Z","timestamp":1788311424448,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","award":["ALF 2023\u2010YF0030"],"award-info":[{"award-number":["ALF 2023\u2010YF0030"]}],"id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005753","name":"Kungliga Fysiografiska S\u00e4llskapet i Lund","doi-asserted-by":"publisher","award":["42795"],"award-info":[{"award-number":["42795"]}],"id":[{"id":"10.13039\/501100005753","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011777","name":"Scandinavian Society for Antimicrobial Chemotherapy Foundation","doi-asserted-by":"publisher","award":["SLS\u2010986553"],"award-info":[{"award-number":["SLS\u2010986553"]}],"id":[{"id":"10.13039\/501100011777","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006738","name":"Medicinska Fakulteten, Lunds Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010823","name":"Tore Nilsons Stiftelse f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["2022\u2010006"],"award-info":[{"award-number":["2022\u2010006"]}],"id":[{"id":"10.13039\/100010823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010823","name":"Tore Nilsons Stiftelse f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["2023\u2010073"],"award-info":[{"award-number":["2023\u2010073"]}],"id":[{"id":"10.13039\/100010823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","award":["SLS\u2010984649"],"award-info":[{"award-number":["SLS\u2010984649"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003173","name":"Crafoordska Stiftelsen","doi-asserted-by":"publisher","award":["20230633"],"award-info":[{"award-number":["20230633"]}],"id":[{"id":"10.13039\/501100003173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To examine whether vulvovaginal candidiasis (VVC) precedes type 2 diabetes and to quantify the possible time period between VVC and subsequent diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide retrospective primary healthcare study including 1\u2009838\u2009929 women aged 35\u201365\u2009years in Sweden (2007\u20132018). Cox regression models were used to examine associations between VVC and type 2 diabetes, while controlling for possible confounders. Propensity\u2010score\u2010weighted analysis was also conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The incidence rate of diabetes per 1000 person\u2010years was 3.06 (95% confidence interval [CI] 3.05\u20133.08) in women without preceding VVC and 4.05 (95% CI 3.86\u20134.24) in women with preceding VVC. The incidence rate was particularly high in women aged 55\u2009years and older with VVC: 9.56 (95% CI 8.01\u201311.11). Women with VVC had a hazard ratio (HR) of 1.41 (95% CI 1.28\u20131.55) for diabetes compared to women without VVC in the multivariable\u2010adjusted model. The corresponding HR was 1.63 (95% CI 1.53\u20131.74) in propensity\u2010score\u2010weighted analysis. Women with prior VVC also seemed to have a stronger risk of diabetes with older age, particularly after the age of 55\u2009years. The mean (range) time between VVC and subsequent diabetes was 0.57\u2009(0\u20132)\u2009years, depending on the age of the woman.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found temporal associations between VVC and diabetes. The findings demonstrate that the presence of VVC may indicate a future diagnosis of diabetes, especially in women aged 55\u2009years and older. This knowledge could be valuable for clinicians when treating women with VVC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15757","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:25:03Z","timestamp":1720484703000},"page":"4043-4051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vulvovaginal candidiasis and type 2 diabetes: A nationwide retrospective cohort study"],"prefix":"10.1111","volume":"26","author":[{"given":"Emelie","family":"Brieditis","sequence":"first","affiliation":[{"name":"Center for Primary Health Care Research, Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"},{"name":"University Clinic Primary Care Sk\u00e5ne  Region Sk\u00e5ne Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"},{"name":"University Clinic Primary Care Sk\u00e5ne  Region Sk\u00e5ne Sweden"},{"name":"Center for Community\u2010Based Healthcare Research and Education (CoHRE), Department of Functional Pathology, School of Medicine Shimane University  Matsue Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0670-9996","authenticated-orcid":false,"given":"Filip","family":"Jans\u00e5ker","sequence":"additional","affiliation":[{"name":"Center for Primary Health Care Research, Department of Clinical Sciences, Malm\u00f6 Lund University  Malm\u00f6 Sweden"},{"name":"University Clinic Primary Care Sk\u00e5ne  Region Sk\u00e5ne Sweden"},{"name":"Department of Clinical Microbiology Center of Diagnostic Investigations, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143084"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14\u20102459"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.14.1884"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201092071\u20109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109118"},{"key":"e_1_2_9_8_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation","year":"2021"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.01.021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2015.1091805"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(18)30103\u20108"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i4.444"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2015.12.233"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.690902"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102334\u20102\u20101"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.13407"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8010076"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2022.100378"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1294"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102458\u201011\u2010450"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010016\u20100117\u2010y"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199712253372607"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2991\/jegh.k.191028.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)62162\u20100"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102796.2000.00748.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010020\u201005253\u2010x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.03.014"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010012\u20102715\u2010x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2014.07.006"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/20503121221115201"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/10647440400003972"}],"container-title":["Diabetes, Obesity and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/pdf\/10.1111\/dom.15757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T05:57:18Z","timestamp":1761890238000},"score":1,"resource":{"primary":{"URL":"https:\/\/dom-pubs.pericles-prod.literatumonline.com\/doi\/10.1111\/dom.15757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,8]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/dom.15757"],"URL":"https:\/\/doi.org\/10.1111\/dom.15757","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/DOM.15757\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15757\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15757\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15757\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15757\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15757\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/DOM.15757\/v2\/review1","asserted-by":"object"}]},"ISSN":["1462-8902","1463-1326"],"issn-type":[{"value":"1462-8902","type":"print"},{"value":"1463-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,8]]},"assertion":[{"value":"2024-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}