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Uncontrolled glucose levels, which occur in patients with T1D as well as type 2 diabetes (T2D), are associated with substantial mortality and cardiovascular disease burden. T2D and T1D share common pathological features of CKD, which is thought to be driven by haemodynamic dysfunction, metabolic disturbances, and subsequently an influx of inflammatory and profibrotic mediators, both of which are major interrelated contributors to CKD progression. The mineralocorticoid receptor is also involved, and, under conditions of oxidative stress, salt loading and hyperglycaemia, it switches from homeostatic regulator to pathophysiological mediator by promoting oxidative stress, inflammation and fibrosis. Progressive glomerular and tubular injury leads to macroalbuminuria a progressive reduction in the glomerular filtration rate and eventually end\u2010stage renal disease. Finerenone, a non\u2010steroidal, selective mineralocorticoid receptor antagonist, is approved for treatment of patients with CKD associated with T2D; however, the benefit of finerenone in patients with T1D has yet to be determined. This narrative review will discuss treatment of CKD in T1D and the potential future role of finerenone in this setting.<\/jats:p>","DOI":"10.1111\/dom.15773","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T03:24:41Z","timestamp":1721273081000},"page":"4135-4146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The potential role of finerenone in patients with type 1 diabetes and chronic kidney disease"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2175-2903","authenticated-orcid":false,"given":"Maria Adelaida","family":"Escobar Vasco","sequence":"first","affiliation":[{"name":"Division of Endocrinology University of Texas Health  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1116-4788","authenticated-orcid":false,"given":"Samuel H.","family":"Fantaye","sequence":"additional","affiliation":[{"name":"Division of Endocrinology University of Texas Health  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-8984","authenticated-orcid":false,"given":"Sapna","family":"Raghunathan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology University of Texas Health  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6215-9418","authenticated-orcid":false,"given":"Carolina","family":"Solis\u2010Herrera","sequence":"additional","affiliation":[{"name":"Division of Endocrinology University of Texas Health  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xkme.2022.100597"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.12.005"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212184"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2022.100438"},{"key":"e_1_2_13_6_1","unstructured":"Centers for Disease Control and Prevention (CDC).Chronic Kidney Disease in the United States.2023. 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