{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:12:19Z","timestamp":1790957539466,"version":"4.1.0"},"reference-count":80,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To synthesize the evidence on the effects of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) in adolescents with overweight or obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>For this systematic review and network meta\u2010analysis, we searched five databases and registries until 2 March 2024 for eligible randomized controlled trials (RCTs). The primary outcome was weight change. We did a pairwise meta\u2010analysis to compare GLP\u20101RAs and placebo, followed by a drug\u2010wise network meta\u2010analysis (NMA) to compare GLP\u20101RAs against each other.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We screened 770 records to include 12 RCTs with 883 participants. The evidence suggests that GLP\u20101RAs reduced weight (mean difference \u22124.21\u2009kg, 95% confidence interval [CI] \u22127.08 to \u22121.35) and body mass index (BMI; mean difference \u22122.11\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , 95% CI \u22123.60 to \u22120.62). The evidence on waist circumference, body fat percentage and adverse events (AEs) was very uncertain. The results remained consistent with subgroup analyses for coexisting type 2 diabetes. Longer therapy duration led to a greater reduction in weight and BMI. In the NMA, semaglutide led to the greatest weight reduction, followed by exenatide, liraglutide and lixisenatide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The evidence suggests that GLP\u20101RAs reduce most weight\u2010related outcomes in adolescents, with semaglutide being the most efficacious. There is uncertain evidence on body fat and serious AEs, probably due to fewer studies and low incidence, respectively. Larger RCTs with head\u2010to\u2010head comparisons, pragmatic design, adiposity\u2010related outcomes, and economic evaluation can further guide the use and choice of GLP\u20101RAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15777","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T23:36:42Z","timestamp":1721777802000},"page":"4302-4317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<scp>Glucagon\u2010like peptide<\/scp>\n                    \u20101 receptor agonists in adolescents with overweight or obesity with or without type 2 diabetes multimorbidity\u2014a systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3418-8171","authenticated-orcid":false,"given":"Muhammad Aaqib","family":"Shamim","sequence":"first","affiliation":[{"name":"Department of Pharmacology All India 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