{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:50:37Z","timestamp":1791521437939,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To provide guidance for follow\u2010up and monitoring of children and adolescents identified as positive to islet autoantibodies (IA) in the general population screening for type 1 diabetes (T1D) in Italy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Detection of IA helps to diagnose pre\u2010symptomatic T1D, prevent diabetic ketoacidosis (DKA) and identify persons for new therapies to delay symptomatic diabetes. Italy recently became the first country to approve by law a general autoantibody screening program for T1D and celiac disease in all children and adolescents (age 1\u201017yr). A pilot study is currently underway in four Italian regions addressing feasibility issues to be used in the scale up to nationwide screening. Meanwhile, a group of experts developed guidance recommendations for follow\u2010up and monitoring of identified IA positive persons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten key components have been identified: establishment of a registry for children and adolescents at risk; close collaboration with the national network of family paediatricians; creation of T1D centers with expertise in follow\u2010up and monitoring; educational measures; assurance of solid IA tests; identification of appropriate metabolic tests; feed\u2010back feasibility and acceptability questionnaires; potential access to available therapeutic interventions; valuable outcome measures including DKA incidence; costs monitoring. Distinctive features of this program include single (in addition to multiple) IA antibody\u2010positive persons in follow\u2010up and the use of CGM to assess risk progression, rather than the cumbersome OGTT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is expected that the proposed follow\u2010up and monitoring program will be effective, affordable and acceptable to children and families identified in general T1D screening in Italy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15779","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T03:59:02Z","timestamp":1721966342000},"page":"4197-4202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Follow\u2010up and monitoring programme in children identified in early\u2010stage type 1 diabetes during screening in the general population of Italy"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-1475","authenticated-orcid":false,"given":"Valentino","family":"Cherubini","sequence":"first","affiliation":[{"name":"Department of Women's and Children's Health Azienda Ospedaliero\u2010Universitaria, Ospedali Riuniti di Ancona, G. Salesi Hospital  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enza","family":"Mozzillo","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, Section of Pediatrics, Regional Center of Pediatric Diabetes Federico II University of Naples  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Iafusco","sequence":"additional","affiliation":[{"name":"Department of Woman, Child and General and Specialistic Surgery, Regional Center of Pediatric Diabetes University of Campania L. Vanvitelli  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Bonfanti","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Diabetology, Department of Pediatrics Diabetes Research Institute, Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Ripoli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Microcythemia ARNAS G. Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Pricci","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Endocrine\u2010Metabolic Diseases, and Aging Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olimpia","family":"Vincentini","sequence":"additional","affiliation":[{"name":"Department of Food Safety, Nutrition and Veterinary Public Health Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Agrimi","sequence":"additional","affiliation":[{"name":"Department of Food Safety, Nutrition and Veterinary Public Health Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Silano","sequence":"additional","affiliation":[{"name":"Unit of Human Nutrition and Health, Department of Food Safety, Nutrition and Veterinary Public Health Istituto Superiore di Sanit\u00e0  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ulivi","sequence":"additional","affiliation":[{"name":"Fondazione Italiana Diabete (FID)  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"D'Avino","sequence":"additional","affiliation":[{"name":"Federazione Italiana Medici Pediatri (FIMP)  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Lampasona","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, IRCCS San Raffaele Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-2495","authenticated-orcid":false,"given":"Emanuele","family":"Bosi","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute, IRCCS San Raffaele Hospital  Milan Italy"},{"name":"Vita\u2010Salute 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