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Patients with diabetes who initiated treatment with a GLP1RA or SGLT2i between 1 May 2016 and 31 December 2017, were identified. Patients were divided into those with or without a previous diagnosis of DR and then categorized into the GLP1RA and the SGLT2i groups according to drug use. The primary outcome of interest in the DR group was the composite of new\u2010onset proliferative DR, vitreous haemorrhage and tractional retinal detachment (RD). In the non\u2010DR group, the primary outcome was the composite of newly diagnosed DR of any severity, vitreous haemorrhage and RD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 97\u2009413 patients were identified. After matching, 1517 patients were treated with a GLP1RA and 3034 with an SGLT2i in the DR cohort. In the non\u2010DR cohort, 9549 initiated a GLP1RA and 19\u2009098 initiated an SGLT2i. In patients with pre\u2010existing DR, the incidence of any DR progression event was significantly higher in the GLP1RA group than the SGLT2i group (subdistribution hazard ratio 1.50, 95% confidence interval 1.01\u20102.23), primarily because of the increased risk of tractional RD. In patients without DR at baseline, the risks of all ocular outcomes were similar between the GLP1RA and SGLT2i groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with diabetes mellitus and established DR, GLP1RA treatment was associated with increased risks of DR progression compared with SGLT2i use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15788","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T04:24:14Z","timestamp":1721363054000},"page":"4386-4396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Incidence and progression of diabetic retinopathy in patients treated with glucagon\u2010like peptide\u20101 receptor agonists versus sodium\u2010glucose cotransporter 2 inhibitors: A population\u2010based cohort study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-6513","authenticated-orcid":false,"given":"Donna Shu\u2010Han","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Shin Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Yun","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital Hsin\u2010chu branch  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Chih","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital Hsin\u2010chu branch  Hsinchu Taiwan"},{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting\u2010Tse","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Cardiovascular Centre National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen\u2010Kuang","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Cardiovascular Centre National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Laboratory Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Telehealth Centre National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University College of Medicine  Taipei Taiwan"},{"name":"Cardiovascular Centre National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"International Diabetes Federation.IDF Diabetes Atlas 10th edition. 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