{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:40:51Z","timestamp":1793148051227,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["1401\u20103\u2010212\u201062416"],"award-info":[{"award-number":["1401\u20103\u2010212\u201062416"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the impact of intermittent fasting, with or without probiotic supplementation, versus a calorie\u2010restricted diet on anthropometric measures, metabolic status and gonadal variables in women with polycystic ovary syndrome (PCOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a randomized, placebo\u2010controlled, parallel\u2010arm clinical trial. The effects of the 14:10 early time\u2010restricted eating (eTRE) strategy alone or combined with probiotics, on obese women with PCOS, were investigated. Participants were divided into three groups: eTRE plus probiotics (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930), eTRE plus placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) and a control group following a standard three\u2010meal\u2010per\u2010day diet with daily calorie restriction (DCR) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930). Over 8\u2009weeks, various anthropometric, metabolic, menstrual and gonadal variables were assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 90 individuals were included in the study, with a mean body weight of 81.4 kg, and a mean age of 30\u2009years. Mean (standard deviation) weight loss was not different between the groups at week 8 (TRE + probiotic: \u22122.2 [1.6] kg vs. TRE + placebo: \u22122.9 [2.7] kg vs. DCR: \u22122.5 [1.7] kg). Results revealed that, while all three regimes led to reductions in body weight, body mass index, vascular risk indicators, hirsutism and acne scores, there were no statistically significant differences between the eTRE groups and the control group in terms of weight loss, or improvements in metabolic, menstrual and gonadal variables (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.05). Additionally, combining probiotics with eTRE did not benefit hormonal and cardiometabolic factors (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The eTRE alone or eTRE plus probiotics did not result in significantly greater weight loss or improvements in metabolic, menstrual and gonadal variables compared with the standard three\u2010meal DCR diet.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15801","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T23:48:26Z","timestamp":1723679306000},"page":"4468-4479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The effects of time\u2010restricted eating alone or in combination with probiotic supplementation in comparison with a calorie\u2010restricted diet on endocrine and metabolic profiles in women with polycystic ovary syndrome: A randomized clinical trial"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7003-6787","authenticated-orcid":false,"given":"Sepide","family":"Talebi","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakineh","family":"Shab\u2010Bidar","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences  Tehran Iran"},{"name":"Sports Medicine Research Center, Neuroscience Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Moini","sequence":"additional","affiliation":[{"name":"Breast Disease Research Center (BDRC) Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Obstetrics and Gynecology Arash Women's Hospital, Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine, ACECR  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurosh","family":"Djafarian","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences  Tehran Iran"},{"name":"Sports Medicine Research Center, Neuroscience Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms030"},{"issue":"3","key":"e_1_2_10_4_1","article-title":"Lifestyle changes in women with polycystic ovary syndrome","volume":"3","author":"Moran LJ","year":"2019","journal-title":"Cochrane Database Syst 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