{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:22:46Z","timestamp":1790007766749,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["IRTG2804"],"award-info":[{"award-number":["IRTG2804"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0925"],"award-info":[{"award-number":["01GI0925"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess oxytocin's acute glucoregulatory impact in men with type 2 diabetes in the context of our previous findings that oxytocin improves \u03b2\u2010cell responsivity in healthy men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a double\u2010blind, crossover comparison, intranasal oxytocin (24\u2009IU) and placebo, respectively, were administered to 25 fasted men with non\u2010insulin\u2013treated type 2 diabetes (age\u2009\u00b1\u2009standard error of the mean, 63.40\u2009\u00b1\u20091.36\u2009years; body mass index, 27.77\u2009\u00b1\u20090.66\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; HbA1c, 6.86%\u2009\u00b1\u20090.08%; Homeostatic Model Assessment of Insulin Resistance (HOMA\u2010IR, 3.44\u2009\u00b1\u20090.39) 60\u2009minutes before an oral glucose tolerance test (oGTT). Key outcomes were compared with previous results in men with normal weight or obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Oxytocin compared with placebo increased plasma oxytocin concentrations and reduced the heart rate, but did not alter glucose metabolism in the 3 hours after oGTT onset (area under the curve, glucose, 2240\u2009\u00b1\u200980.5 vs. 2190\u2009\u00b1\u200969.5\u2009mmol\/L \u00d7 min; insulin, 45\u2009663\u2009\u00b1\u20094538 vs. 44\u2009343\u2009\u00b1\u20094269\u2009pmol\/L \u00d7 min; C\u2010peptide, 235\u2009\u00b1\u20095.1 vs. 231\u2009\u00b1\u200915.9\u2009nmol\/L \u00d7 min).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This outcome contrasts with the oxytocin\u2010induced attenuation of early postprandial glucose excursions in normal\u2010weight individuals, but is in line with the absence of respective effects in men with obesity. We conclude that insulin resistance in type 2 diabetes is associated with decreased sensitivity to the acute glucoregulatory effect of oxytocin in male individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15812","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T23:56:03Z","timestamp":1723161363000},"page":"4562-4570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oxytocin does not acutely improve glucose tolerance in men with type 2 diabetes"],"prefix":"10.1111","volume":"26","author":[{"given":"Nina","family":"Goll","sequence":"first","affiliation":[{"name":"Department of Medical Psychology and Behavioural Neurobiology University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Moszka","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology and Behavioural Neurobiology University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Department of Periodontics, Preventive and Restorative Dentistry, Center for Dental and Oral Medicine University Medical Center Hamburg Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kantartzis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV University Hospital T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Preissl","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Mental Health (DZPG)  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Gruber","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"},{"name":"Institute for Diabetes and Obesity Helmholtz Diabetes Center, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health  Neuherberg Germany"},{"name":"Van Andel Institute  Grand Rapids Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Fritsche","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV University Hospital T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Jumpertz\u2010von Schwarzenberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV University Hospital T\u00fcbingen  T\u00fcbingen Germany"},{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"},{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Garc\u00eda\u2010C\u00e1ceres","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD)  T\u00fcbingen Germany"},{"name":"Institute for Diabetes and Obesity Helmholtz Diabetes Center, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health  Neuherberg Germany"},{"name":"Medizinische Klinik und Poliklinik IV Klinikum der 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