{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:34:37Z","timestamp":1788453277200,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["dom-pubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Obesity Metabolism"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The relative contributions of insulin secretory defects and possible additional contribution of insulin resistance for the development of cystic fibrosis (CF)\u2010related diabetes (CFRD) are poorly understood. We aimed to (a) determine which indices of insulin resistance predict progression to CFRD, and (b) to model the relative contributions of insulin secretory function and insulin resistance to predict the risk of CFRD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Three hundred and three individuals living with CF underwent a 2\u2010h oral glucose tolerance test with blood sampling every 30\u2009min at 12\u201324\u2010month intervals until they developed CFRD or until the end of follow\u2010up (up to 15\u2009years). Indices of insulin resistance (e.g. Stumvoll) and insulin secretion were calculated from oral glucose tolerance test glucose and insulin measurements. CFRD\u2010free survival was assessed by survival analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Estimated insulin resistance showed associations with glucose homeostasis and risk of progression to CFRD. The CFRD\u2010free survival was significantly different between quartiles of insulin resistance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). When patients were subdivided according to both insulin resistance and insulin secretion (insulinogenic index), CFRD\u2010free survival was significantly lower in those with combined lowest insulin secretion and highest insulin resistance (Stumvoll) indices (hazard ratio: 11.2;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). There was no significant difference when the same analysis was performed for the nine other indices.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Insulin resistance is correlated with glucose homeostasis and the risk of progression to CFRD. Patients combining low insulin secretion and high insulin resistance had the greatest odds of developing CFRD over a 15\u2010year period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15844","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T05:40:57Z","timestamp":1723182057000},"page":"4744-4752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cystic fibrosis\u2010related diabetes develops from a combination of insulin secretion defects and insulin resistance"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3148-8956","authenticated-orcid":false,"given":"Marie\u2010\u00c8ve","family":"Bolduc","sequence":"first","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn 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Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Research Centre of H\u00f4pital du Sacr\u00e9\u2010C\u0153ur de Montr\u00e9al, Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux (CIUSSS) du Nord\u2010de\u2010l'\u00cele\u2010de\u2010Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Alexandre\u2010Heymann","sequence":"additional","affiliation":[{"name":"Montreal Clinical Research Institute (IRCM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Cystic Fibrosis Clinic Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec 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