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Recently, the discovery of cuproptosis, a newly identified mode of cell death, further highlighted the importance of copper in maintaining metabolic homeostasis. An increasing number of studies have confirmed that liver copper metabolism is closely related to the pathogenesis of NAFLD. However, the relationship between NAFLD and copper metabolism, especially cuproptosis, remains unclear. In this review, we aim to summarize the current understanding of copper metabolism and its dysregulation, particularly the role of copper metabolism dysregulation in the pathogenesis of NAFLD. More importantly, this review emphasizes potential gene\u2010targeted therapeutic strategies, challenges and the future of cuproptosis\u2010related genes in the treatment of NAFLD. This review aims to provide innovative therapeutic strategies for NAFLD.<\/jats:p>","DOI":"10.1111\/dom.15846","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T02:48:51Z","timestamp":1725504531000},"page":"4830-4845","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Copper homeostasis and cuproptosis\u2010related genes: Therapeutic perspectives in non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0038-6260","authenticated-orcid":false,"given":"Wangjing","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Acupuncture and Moxibustion, College of Acupuncture\u2010Moxibustion and Orthopedics Hubei University of Chinese Medicine  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of 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