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Men reported symptoms later than women. Symptom onset was earlier in FPLD2. Fat loss was less prominent in FPLD3. In total, 92 subjects (59%) had diabetes (age at diagnosis: 34\u2009\u00b1\u20091\u2009years). Retinopathy was more commonly detected in FPLD3 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Severe hypertriglyceridaemia was more frequent among patients with FPLD3 (44% vs. 17%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.01). Hepatic steatosis was detected in 100 subjects (66%) (age at diagnosis: 36\u2009\u00b1\u20092\u2009years). Coronary artery disease developed in 26 patients (17%) and 17 (11%) suffered from a myocardial infarction. Turkish patients had a lower body mass index, a higher prevalence of hepatic steatosis, greater triglyceride levels and a tendency towards a higher prevalence of coronary artery disease. A total of 17 patients died, with a mean time to death of 75\u2009\u00b1\u20093\u2009years, which was shorter in the Turkish cohort (68\u2009\u00b1\u20092 vs. 83\u2009\u00b1\u20094\u2009years,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.01). Cardiovascular events were a major cause of death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our analysis highlights severe organ complications in patients with FPLD, showing differences between genotypes and Mediterranean countries. FPLD3 presents a milder phenotype than FPLD2, but with comparable or even greater severity of metabolic disturbances.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/dom.15882","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T15:30:38Z","timestamp":1724340638000},"page":"4875-4886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A cohort analysis of familial partial lipodystrophy from two Mediterranean countries"],"prefix":"10.1111","volume":"26","author":[{"given":"Ant\u00eda","family":"Fern\u00e1ndez\u2010Pombo","sequence":"first","affiliation":[{"name":"UETeM\u2010Molecular Pathology Group, Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, IDIS\u2010CIMUS University of Santiago de Compostela  Santiago Spain"},{"name":"Division of Endocrinology and Nutrition University Clinical Hospital of Santiago de Compostela  Santiago 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I.","family":"Castro","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Nutrition University Clinical Hospital of Santiago de Compostela  Santiago Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBERobn)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Atik","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Ege University Faculty of Medicine  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Loidi","sequence":"additional","affiliation":[{"name":"Galician Public Foundation for Genomic Medicine (SERGAS\u2010Xunta de Galicia)  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Onay","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Ege University Faculty of Medicine  Izmir 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